Discussion in 'Latest ME/CFS Research' started by Dolphin, Mar 20, 2017.
Free full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165790/
The abstract doesn't make clear that there were 2 ways of measuring the cortisol awakening response and only one was related to PSMS or PEM severity:
I think a lot of people would consider the CARi as the more specific measure of the cortisol awakening response. The CARg is more like the total cortisol rather than something specific to the cortisol awakening response.
They didn't use the other 2 cortisol measurements so one can't tell whether the same findings would hold up if one also used the other to cortisol measurements (i.e. later in the day).
Makes sense to me. Very stressful times in my life saw my cfs deteriorate. I dealt with the stress (quit my job) and eventually got out of decline and back to a path where I've been able to improve.
The questionnaire on the website has 23 questions. I'm not sure why there are more than 17 questions mentioned in the description but I haven't looked closely.
If the CAR is related to the symptom "difficulties getting up in the morning", then I suspect this is just an indicator of being in PEM (or having messed up sleep cycles).
Thinking about it, I'm not sure if there have been studies that actually test the intervention "PEM education and activity reduction" in newly diagnosed patients.
The authors do briefly mention other ways the data can be looked at:
Illness severity might be an independent variable associated with both PEM and cortisol levels.
These researchers are reaching a conclusion first and then looking for data to justify it ... im sick of people trying to insinuate that we are suffering from stress, anxiety etc
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