had very bad couple of weeks, often having to go back to sleep after waking to recover from waking up! ick! (waking is always my worst period) Not sure if it was the actual cause somehow, or came about because of this bad patch, but I got very unpleasant sore throat. Pretty sure the sore throat's related to eating salted peanuts, at that time, whether a "bad bag" of nuts (perhaps after having had them open a few days they have got some mould or such but unusual if so as the salt usually keeps them fine), or because the M.E. was so severe my immune system started acting against the peanuts *shrug* I do not have ANY allergies (1), but it's certainly possible from everything I've read or experienced that M.E. can set up feedback cycles of unusual immune reactions. Anyway, I took plain old Strepsils (well new blue ones anyway), for the sore throat, after finally finding the mental strength to think about it and do a hunt for 'em. (2) For those not familiar, Strepsils are a UK well known brand of throat lozenges to help with sore throats etc Holy crap! not only did it help the throat it also had just as quick a difference in the "depression" and other mental crap that I'd been suffering! it was too sudden too unusual to be any kind of mood swing or whatever, hey I know myself, you know You do get ups and downs, but not like this. Pretty sure reducing the sore throat improved mental state. Depression is *NOT* being "down" it damn well is "physical" somehow and to some extent, never been a depressive person in my life but plenty of crap to get you "down" now and then, and the difference is night and day. yes, having most of my life, what I "do" and care about, destroyed by this illness is massively upsetting etc , even so, depression and other mental issues like my short term memory is ruined, problems seeing words I've typed are wrong etc are not psychological. I know the worst thing for my M.E. is having an infection, as that sets it off terribly. So I wonder, from what I've read on M.E. and many other illnesses once thought of or accused of being "psychological" like O.C.D. (3), that calming the infection or immune reaction then helped calm down a cycle of autoimmunity that causes some of the mental issues the difference is VERY noticeable. I simply don't get "swings" or changes anything like this except over long period of time as warm, drier weather of late Summer eases things and cold damp Winter (as in now!) makes the M.E better or worse. Most interesting! Mind is much clearer, still not a like I used to be but hell of a sight better than last few years, and still physically wrecked by the M.E. (1) I have "allergies" to poverty and arrogant, cowardly, vicious bullying SOBs like, the psychs, but hey, I think that's obvious! (2) Folk unaffected by such ailments simply have no idea how hard it can be, to do the simplest bloody things, and it has NOTHING to do with how strong willed etc you were before. (3) I recall reading an article some 30 or so years ago now, of a man who had severe OCD, they found by pure accident (he got an infection they prescribed an antibiotic and "cured" his OCD while the antibiotic worked)that as long as he was kept dosed with a form of antibiotic, the OCD was almost completely gone/controlled when he accidentally forgot to take his prescription he nearly died as a result of his OCD coming back and pushing him to do something extremely dangerous. Always remember that article. Oh and it's and NOT like the psychs could have made a complete arrogant stupid balls up and not accepted that many mental health conditions could be related to autoimmunity, is it? *he says with sarcasm set in Maximum Overdrive mode* or, fact that some pathogens create incredibly potent poisons some of which can affect the brain (L.S.D. for example! or the sudden extreme psychosis that bladder infections can trigger).