Forgive me if there is a better subforum, i'm just getting a handle on PR. I've had CFS for many years now, diagnosed by 5 drs in the last 3 years and been deteriorating rapidly. The "episodes" are more sever, longer duration and more frequent. I recently got a sore throat and was diagnosed with strep. This was during a rather sever, lengthy episode, with major cognitive issues (feeling like a zombe, unable to concentrate, lethargy, etc) I started taking amoxacilin and my cognitive issues started improving modestly after 12 hours. Then they started to get much worse, and so did my sore throat, also spreading to my ears and chest. Dr. switched me to a Z-pack (azithromycin) and 8 hours later, my head started clearing up. I started to feel human! Woke up with a relatively clear head. Now after 24 hours my throat is getting worse, but mild CSF issues and not sure if i'm able to affect the strep with z-pack and may move to a stronger antibiotic. My initial thought was that the strep, like my recurrent sinus problems or other environmental / diet factors, is triggering my autoimmune system and that is connected to the auto-immune side of CSF. Then I started to wonder if it was the strep bacteria itself.... what if the exotoxin from strep bacteria (d-lactic Acid) was triggering my symptoms? So I started to look into this and found: http://www.ncbi.nlm.nih.gov/pubmed/19567398 showing a connection. I also learned that strep is in the digestive process and breaks down sugar, again releasing d-lactic acid and causing d-lactic acidosis (http://emedicine.medscape.com/article/167027-overview) and can cause very similar symptoms like fatigue, weakness, cognitive impairment, etc. I was wondering if the community had similar difficulty with strep or thinks this may be a connection i could consider treating (ie. going after strep bacteria in my body or removing the d-lactic acid.) Any thoughts appreciated.