I used to travel down these roads: Strattera, Concerta, Adderall XR, Vyvanse, Intuinv. Without fail, they all felt good at first and then eventually felt like an energized straight jacket for my mind, like a horse with blinders, a hyper-focus with no end. With the Vyvanse in particular, on the first day, after not using it for a long time, I would get the initial dopamine drop or flush and it would feel like God was sitting in my lap. I just marveled at life the whole day. From there it got worse until it seemed like I had the devil on my shoulder, beseeching me to be ever vigilant, obsessively focusing on the most minute of details, to the point of slowly dropping off in effect as though I was then of two minds in one long day, before I realized that I needed rest, but then the taskmaster again in the morning after a short time of rather agitated sleep. I found Pristique with its SNRI approach to me just as annoying and lead to migraines that lead to an ER visit that led me to stopping it. Now I just say No. But they work differently for all, so if there is benefit, then that is great.