For over 10 years, since a drug use gone wrong happened, I've had a strange mast-cell phenomenon happening. It started with an ecstacy tablet that left my arms and legs rushing with numbness and a panic that set in throughout my body. A couple days later, I developed the condition Chronic Urticaria (hives) which was in full effect for several years, but now in remission. Through this experience, a couple of strange and seemingly unique reactions occurred: 1) The drugs Zyrtec, Allegra and Benadryl were attempted to resolve the hives. Instead of providing any relief, each drug produced more hives to appear all over the body; except for the face. It was not a true allergic reaction (i.e. Anaphylactic shock). Just a bundle of hives that covered my body for a couple days after the trial. 2) Alcohol resolved my Cholinergic Urticaria condition entirely. Not rubbing alcohol, but drinking alcohol like beer and liquor. Only a couple shots were necessary, but once I had ingested a few drinks, I no longer had any hives on my skin what-so-ever. Can anyone relate to these experiences or know of any similar ones? I have not yet been able to pin-down the dysfunctional cause of this.