Hello, I'll try to be brief with background. Healthy and very active until 50 years old. Stress contributed to development of chronic insomnia, candida, carb intolerance, abdominal pain/bloating, brain fog, then muscle weakness/spasms, continually swollen glands, intolerance to stress, fatigue, malaise, and frequent viral outbreaks (including HSV1, HPV, mono, Herpes zoster...). On the plus side, I started olive leaf extract 5 months ago and have been amazed at the improvement in my gut. I still struggle with fatigue and muscle weakness/spasms , so I am revisiting the methylation protocol which I first researched when I discovered that I had MTHFR 677 and 1298 mutations. In the past, I have tried methyl b12 (capsules, subcutaneous, sublingual, liquid, and sprays). Even the smallest amounts put me into hyperdrive (can't sleep at all, talk a million miles an hour) and feel that my vascular system is going to explode. This effect gets worse with time. SAM-e, TMG, all vitamin supplements, and glutamine do the same thing. I think I understand from Freddd's postings that I need to start with adenosylcobalamin. Unfortunately, I read the list of supplements just before his new posting recommending the removal of folic acid. I started Country Life 3000 mcg a week ago by taking 1/8 of a tablet at regular intervals throughout the day. Low and slow. I moved up to 1/4 tablet by the end of the week (throughout day) along with 1/4 tablet Jarrow 1000 mcg methyl b12 (this addition seemed to lessen the hyperactivity a bit, but I'm still battling insomnia). What next? Once I get my sleep under control, should I add small amounts of methyl folate throughout the day? Or B-complex? TMG? Does olive leaf extract contribute to methylation in any way? It has helped my overall well being so much....I have to wonder.