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Stiff-Person Syndrome?

Discussion in 'Immunological' started by merylg, Oct 12, 2012.

  1. merylg

    merylg Senior Member

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    Sydney, NSW, Australia
    "The disorder is often misdiagnosed as Parkinson’s disease, multiple sclerosis, fibromyalgia, psychosomatic illness, or anxiety and phobia. A definitive diagnosis can be made with a blood test that measures the level of glutamic acid decarboxylase (GAD) antibodies in the blood. People with SPS have elevated levels of GAD, an antibody that works against an enzyme involved in the synthesis of an important neurotransmitter in the brain."

    "
    A study using the drug rituximab proved ineffective in treating individuals with the disorder. "
    http://www.ninds.nih.gov/disorders/stiffperson/stiffperson.htm

    http://www.hopkinsmedicine.org/neur...ections/conditions/stiff_person_syndrome.html

    Interesting treatments? Intravenous Immune Globulin (IVIg)....Plasmapheresis...Valerian...think I would avoid Benzos and GABA-acting meds...
     
  2. merylg

    merylg Senior Member

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    Sydney, NSW, Australia
  3. Marco

    Marco Old blackguard

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    Near Cognac, France
    meryl Is it not that GABA is inhibited by GAD antibodies?

    Also interesting links to entero and coxsackie virus infection :

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921245/
     
    merylg likes this.
  4. merylg

    merylg Senior Member

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    Sydney, NSW, Australia
    "Benzodiazepines and other GABA-acting medications remain essential to managing the stiffness and spasms of SPS. If these medications are withdrawn from SPS patients, the muscle rigidity can be over-whelming and fatal respiratory compromise occur." :eek:

    http://www.hopkinsmedicine.org/neur...ections/conditions/stiff_person_syndrome.html

    http://www.ataxiacenter.umn.edu/aboutataxia/sporadic/gad/home.html

    Yes, stops you making GABA and in theory something like Gabapentin is supposed to mimic the action of GABA...but they don't really know what receptors it targets! Scary thought! Scary drug (I had a bad experience)...


    http://en.wikipedia.org/wiki/Gabapentin

    Thanks for the link, Marco.
     
  5. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    australia (brisbane)
    they think gabapentines effects are through its actions as a calcium channel blocker which can help turn down pain signals. I remember reading that they didnt think gabapentine had any effects at all on gaba receptors
     
    merylg likes this.

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