Dear Members, I am pleased to inform you of a renewed effort to focus attention on stealth adapted viruses as the cause of CFS. I did so by submitting the following public comment to the Institute’s of Medicine Committee for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Dear Sir, Members of the Committee on Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome could benefit by learning about stealth adapted viruses. These viruses lack the relatively few virus coded components normally targeted by the cellular immune system. The brain is particularly susceptible to symptomatic illness caused by stealth adapted viruses. Based on extensive virus culture studies, these illnesses include the chronic fatigue syndrome (1). Government sponsored reluctance in accepting the existence of stealth adapted viruses is mainly because of the unequivocal origin of some of these viruses from the kidneys of monkeys used to generate polio virus vaccines (2). Fortunately, the body has an effective non-immunological defense mechanism mediated by the alternative cellular energy (ACE) pathway. This pathway can suppress both stealth adapted and conventional viruses and can be easily enhanced through the consumption of enerceutical foods and activated liquids and by other methods. It is time for an international effort to redefine a major category of illnesses with impaired brain functioning as stealth adapted virus encephalopathy. Efforts to overly sub-classify this heterogeneous grouping of illnesses are far less important than moving forward with effective prevention and treatment strategies. The Institute of Medicine committee members could help in these efforts by learning more about stealth adapted viruses and the ACE pathway and by openly discussing and resolving the politically sensitive issues with senior public health officials. 1. Martin WJ et al. Cytomegalovirus-related sequence in an atypical cytopathic virus repeatedly isolated from a patient with chronic fatigue syndrome. Am. J. Pathol. 145: 440-451, 1994. (Available online via PubMed). 2. Martin WJ et al. African green monkey origin of the atypical ‘stealth virus’ isolated from a patient with chronic fatigue syndrome. Clin. Diag. Virol. 4: 93-103, 1995. Sincerely, W. John Martin, MD, PhD.