The 12th Invest in ME Conference, Part 1
OverTheHills presents the first article in a series of three about the recent 12th Invest In ME international Conference (IIMEC12) in London.
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STAT5 programs a distinct subset of GM-CSF-producing T helper cells that is essential for autoimmune

Discussion in 'Other Health News and Research' started by Bob, Dec 2, 2014.

  1. Bob

    Bob

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    I came across this recently, and thought it might be interesting to some who are interested in immunology and immune cells... It's technically way-beyond me, but I'm slowly learning about immune cells etc.

    The research is specifically in relation to MS, but seems that it might be relevant to other conditions...

    The full paper is available for those who want to get stuck into the detail...

    STAT5 programs a distinct subset of GM-CSF-producing T helper cells that is essential for autoimmune neuroinflammation
    Wanqiang Sheng, Fan Yang, Yi Zhou, Henry Yang, Pey Yng Low, David Michael Kemeny, Patrick Tan, Akira Moh, Mark H Kaplan, Yongliang Zhang and Xin-Yuan Fu.
    Cell Research (2014) 24:1387–1402. doi:10.1038/cr.2014.154; published online 21 November 2014
    http://www.nature.com/cr/journal/v24/n12/full/cr2014154a.html

     
    Last edited: Dec 2, 2014
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  2. Bob

    Bob

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    Also, there's an article about the research, here...

    New Insights Into “T Helper Cells” Could Guide Future Multiple Sclerosis Therapies
    December 1, 2014
    by Patricia Inacio, PhD
    Multiple Sclerosis News Today
    http://multiplesclerosisnewstoday.c...ld-guide-future-multiple-sclerosis-therapies/

    It starts...
     
    Last edited: Dec 2, 2014
  3. Bob

    Bob

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    And this is an entirely separate paper, published earlier this year, but it seems to be closely related...

    IL-17 and GM-CSF expression are antagonistically regulated by human T helper cells.
    Noster R, Riedel R, Mashreghi MF, Radbruch H, Harms L, Haftmann C, Chang HD, Radbruch A, Zielinski CE.
    Sci Transl Med. 2014 Jun 18;6(241):241ra80. doi: 10.1126/scitranslmed.3008706.
    http://www.ncbi.nlm.nih.gov/pubmed/24944195
    http://stm.sciencemag.org/content/6/241/241ra80.short

     
  4. Jonathan Edwards

    Jonathan Edwards "Gibberish"

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    Thanks for the flag up, Bob,
    My view is only my view, as you will have gathered, but I have the usual issues with this. The paper is not about MS but about EAE which is a disease caused in mice specially bred to respond to a whacking dose of self antigen plus adjuvant and then given said whacking dose. MS is not caused like that and we have precious little evidence that it shares much in the way of pathways except at the damage stage. I am not that squeamish but I stopped doing this sort of thing to rodents after the first year of my doctoral project - because I had to do it myself and see the effects.

    The second paper is fascinating and Andreas Radbruch, who is good value, is a senior author. The main message seems to be that in humans things are surprisingly different (surprise or maybe not surprise). At least this is about human immunology but I cannot quite see how they link it to MS - unless of course they assume MS is human EAE.

    I may be bonkers but I did manage to get the most widely effective therapeutic agent in autoimmunity licensed despite being told by the T cell people that I was wasting my time. There must be some method in my madness? I think all this T cell stuff is off target but I admit to having been a teeny bit wrong before at times - and am happy to be proved wrong again if it helps.

    My guess would have been that TH17 would be relevant to the real T cell diseases (not autoimmune) like psoriasis and ankylosing spondylitis. I had a look on Wikipedia and it looks as if IL-17 is looking quite good as a psoriasis treatment but nothing else so far. So not wrong just yet.
     
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