Thanks Freddd, then evidence is anecdotal although I have no doubt in this case if there was an appropriate test before and after some change would have been found. I just want to add that anecdotal doesn't imply any lesser of evidence especially when it involves larger number of people. And in fact IMO the internet has completely validated and improved substantially the value of anecdotal information by allowing collection places for first hand accounts such as this forum and allowing everyone to have a "global" voice. We all become part of an ongoing clinical study which is probably our best hope for having anything cured in the future since cures don't seem to be coming from anywhere else these days. Are you referring to when the supps stop the ongoing stimulation of the Methylation cycle or a deeper action of the B12 you indicated in CNS healing? I trust what you say. I think you are the proverbial canary in the coal mine as far as B12 sensitivity goes from what I've been reading here.