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Starting Raltegravir

Discussion in 'XMRV Testing, Treatment and Transmission' started by jimbob, May 27, 2010.

  1. Cloud

    Cloud Guest

    Great News jimbob.....Thanks for sharing....onward!
  2. omerbasket

    omerbasket Senior Member

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    jimbob, these are very good news to hear.
    I hope you'll keep getting better. I guess the there are going to be some "downs" down the long road, but don't be discouraged by them. I hope that you'll have, like until now, much more "highs" than "downs".
  3. ggingues

    ggingues $10 gift code at iHerb GAS343 of $40

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    Concord, NH
    thanks for the update! Hope you continue to feel better with no negative effects!

    GG
  4. Daffodil

    Daffodil Senior Member

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    jim...are you still doing ok?

    i felt better for a while but today was AWFUL again.

    i wish i knew what was going on.

    :-/
  5. jimbob

    jimbob ME/CFS84-XMRV+

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    myrtle beach, s.c.
    Yes, I'm still doing O.K. and crossing my fingers and toes that it will continue. Tomorrow is a month since I started. Im sorry you're having a bad day, hope you bounce back quick. good wishes, Jim
  6. BEG

    BEG Senior Member

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    So good to hear it, jimbob. I sincerely hope things continue on the upswing. BEG
  7. Cort

    Cort Phoenix Rising Founder

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    Given my incredible sensitivity to even some supplements I've wondered as well how I could tolerate any major drugs. I wish someone could get a handle on that hypersensitivity issue - it doesn't seem to be get much interest in the research community - but it seems to me to be a key factor.

    Good luck with the antiretrovirals. :)
  8. silicon

    silicon Senior Member

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    And then there are those who are hypersensitive to the binders/fillers used in various medications and supplements (at least sometimes it may be possible to have a compounding pharmacy use alternative binders/fillers).
  9. Cloud

    Cloud Guest

    I have always believed medication sensitivity to be a KEY factor because for me it was there from the very start; In the very beginning of the illness when it was thought I was just becoming depressed, I had severe medication intolerance problems. Also, it's the one and only symptom that has remained constant throughout my 17 years with ME/CFS.
  10. aquariusgirl

    aquariusgirl Senior Member

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    geminia what's the test to predict drug tolerance?
    is it genovations detoxigenomics?
  11. Gemini

    Gemini Senior Member

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  12. jimbob

    jimbob ME/CFS84-XMRV+

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    myrtle beach, s.c.
    what's odd is that I couldn't tolerate any high doses of antidepressants over the years, yet for a month now i've been doing 800mg a day of Ral and tolerating it so far. Go figure!
  13. Rrrr

    Rrrr Senior Member

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    jimbob, are you on any other meds besides the ral?

    warmly
    rrrr (boston misses you!)
  14. Gemini

    Gemini Senior Member

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    jimbob,

    it could be because--
    RAL is not metablolized by P450 enzymes,
    antidepressants are.

    and chronic infections, immune activation & cytokine exposure
    dysregulate P450 enzymes.

    ThePharmaLetter, October 22, 2007, excerpt:
    Merck also reported data from a series of drug interaction studies, which demonstrated that no adjustment in Isentress dosage was required when co-administered with other antivirals. The firm added that its product is not metabolized by cytochrome P450 enzymes, and therefore has an extended therapeutic half-life.


    Gemini
  15. jimbob

    jimbob ME/CFS84-XMRV+

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    myrtle beach, s.c.
    Rrrr, just crestor 5mg, Zoloft 25mg every other day, .5mgativan and Halcion .50mg for sleep. Not much compared to most. Jim GO REDSOX/PATRIOTS/CELTICS!
  16. Cloud

    Cloud Guest

    I had hoped Ral was not metabolized via P450 which for me is obviously the route of metabolism that causes my medication intolerance issues. I hadn't yet looked this up......thanks for sharing.
  17. grant107

    grant107 Jean

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    jimbob, what lab work are you having done. I thought probably liver and kidney function tests.
  18. jimbob

    jimbob ME/CFS84-XMRV+

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    myrtle beach, s.c.
    setting up lab work this week, checking those 2 for sure!
  19. citybug

    citybug Senior Member

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    NY
    Broccoli is generally recommended and other vegs high in antioxidants.
  20. ggingues

    ggingues $10 gift code at iHerb GAS343 of $40

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    Concord, NH
    You from these parts? New England that is.

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