New era for ME/CFS research as top cytokine study attracts media headlines
The immune systems of patients who have recently developed ME/CFS look markedly different from those who have been ill for much longer, according to a major new study from Drs. Ian Lipkin and Mady Hornig at Columbia University. This shift in immune function hadn’t been seen before.
Discuss the article on the Forums.

Starting Raltegravir

Discussion in 'XMRV Testing, Treatment and Transmission' started by jimbob, May 27, 2010.

  1. Cloud

    Cloud Guest

    Great News jimbob.....Thanks for sharing....onward!
     
  2. omerbasket

    omerbasket Senior Member

    Messages:
    510
    Likes:
    13
    jimbob, these are very good news to hear.
    I hope you'll keep getting better. I guess the there are going to be some "downs" down the long road, but don't be discouraged by them. I hope that you'll have, like until now, much more "highs" than "downs".
     
  3. ggingues

    ggingues $10 gift code at iHerb GAS343 of $40

    Messages:
    4,215
    Likes:
    1,046
    Concord, NH
    thanks for the update! Hope you continue to feel better with no negative effects!

    GG
     
  4. Daffodil

    Daffodil Senior Member

    Messages:
    3,087
    Likes:
    1,147
    jim...are you still doing ok?

    i felt better for a while but today was AWFUL again.

    i wish i knew what was going on.

    :-/
     
  5. jimbob

    jimbob ME/CFS84-XMRV+

    Messages:
    321
    Likes:
    9
    myrtle beach, s.c.
    Yes, I'm still doing O.K. and crossing my fingers and toes that it will continue. Tomorrow is a month since I started. Im sorry you're having a bad day, hope you bounce back quick. good wishes, Jim
     
  6. BEG

    BEG Senior Member

    Messages:
    943
    Likes:
    167
    Southeast US
    So good to hear it, jimbob. I sincerely hope things continue on the upswing. BEG
     
  7. Cort

    Cort Phoenix Rising Founder

    Messages:
    7,033
    Likes:
    479
    Raleigh, NC
    Given my incredible sensitivity to even some supplements I've wondered as well how I could tolerate any major drugs. I wish someone could get a handle on that hypersensitivity issue - it doesn't seem to be get much interest in the research community - but it seems to me to be a key factor.

    Good luck with the antiretrovirals. :)
     
  8. silicon

    silicon Senior Member

    Messages:
    148
    Likes:
    72
    And then there are those who are hypersensitive to the binders/fillers used in various medications and supplements (at least sometimes it may be possible to have a compounding pharmacy use alternative binders/fillers).
     
  9. Cloud

    Cloud Guest

    I have always believed medication sensitivity to be a KEY factor because for me it was there from the very start; In the very beginning of the illness when it was thought I was just becoming depressed, I had severe medication intolerance problems. Also, it's the one and only symptom that has remained constant throughout my 17 years with ME/CFS.
     
  10. aquariusgirl

    aquariusgirl Senior Member

    Messages:
    1,013
    Likes:
    146
    geminia what's the test to predict drug tolerance?
    is it genovations detoxigenomics?
     
  11. Gemini

    Gemini Senior Member

    Messages:
    419
    Likes:
    392
  12. jimbob

    jimbob ME/CFS84-XMRV+

    Messages:
    321
    Likes:
    9
    myrtle beach, s.c.
    what's odd is that I couldn't tolerate any high doses of antidepressants over the years, yet for a month now i've been doing 800mg a day of Ral and tolerating it so far. Go figure!
     
  13. Rrrr

    Rrrr Senior Member

    Messages:
    1,404
    Likes:
    291
    jimbob, are you on any other meds besides the ral?

    warmly
    rrrr (boston misses you!)
     
  14. Gemini

    Gemini Senior Member

    Messages:
    419
    Likes:
    392
    jimbob,

    it could be because--
    RAL is not metablolized by P450 enzymes,
    antidepressants are.

    and chronic infections, immune activation & cytokine exposure
    dysregulate P450 enzymes.

    ThePharmaLetter, October 22, 2007, excerpt:
    Merck also reported data from a series of drug interaction studies, which demonstrated that no adjustment in Isentress dosage was required when co-administered with other antivirals. The firm added that its product is not metabolized by cytochrome P450 enzymes, and therefore has an extended therapeutic half-life.


    Gemini
     
  15. jimbob

    jimbob ME/CFS84-XMRV+

    Messages:
    321
    Likes:
    9
    myrtle beach, s.c.
    Rrrr, just crestor 5mg, Zoloft 25mg every other day, .5mgativan and Halcion .50mg for sleep. Not much compared to most. Jim GO REDSOX/PATRIOTS/CELTICS!
     
  16. Cloud

    Cloud Guest

    I had hoped Ral was not metabolized via P450 which for me is obviously the route of metabolism that causes my medication intolerance issues. I hadn't yet looked this up......thanks for sharing.
     
  17. grant107

    grant107 Jean

    Messages:
    92
    Likes:
    0
    Ormond Beach, Fl
    jimbob, what lab work are you having done. I thought probably liver and kidney function tests.
     
  18. jimbob

    jimbob ME/CFS84-XMRV+

    Messages:
    321
    Likes:
    9
    myrtle beach, s.c.
    setting up lab work this week, checking those 2 for sure!
     
  19. citybug

    citybug Senior Member

    Messages:
    522
    Likes:
    36
    NY
    Broccoli is generally recommended and other vegs high in antioxidants.
     
  20. ggingues

    ggingues $10 gift code at iHerb GAS343 of $40

    Messages:
    4,215
    Likes:
    1,046
    Concord, NH
    You from these parts? New England that is.
     

See more popular forum discussions.

Share This Page