I think it was in 2007, a doctor started me on LDN. I knew very little about it and he should have known better, but he started me off on 4 mgs right off the bat. Needless to say I didn't sleep and never went back to it. Now I have .5 mgs and I'll stay with that for 2 weeks and then go again in 2 more weeks. I've been through a bad spell with sleep lately and I'm not looking forward to the possibility of not sleeping again. I've read some people here said they went really slowly and took a long time to get to the full dose they can tolerate so I'm wondering if I should have gotten .25 mgs. But if I have to I can always open these and do it that way. I know I have to take it at night. Can someone tell me when, with food? I turn off the lights at 10 pm. Thanks for the help.