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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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Make sure you don't take potassium at the same time as methylfolate. Potassium and vitamin c (especially ascorbic acid) block methylfolate absorption in the gut. If you're taking it sublingually (such as with Solgar's Metafolin) this might not be as much of an issue.
I was on Rich's protocol for about 3 months with differing doses. I went up to 3.2mg of metafolin and around I had used perqueB12 and also some meB12. The meB12 was not sustained very long though.
My metabolic profile showed lots of plasma fatty acids were at the high end. Rich said this was likely due to a lack of NADH which "presents" the fatty acids to the mitochondria. I took 50mg NAD per day and my liver enzymes went through the roof! This is good evidence that B3 does reduce methylation function but I feel it is only of consequence when there is a lack of methylation and possibly not when the MTR enzyme is being "topped-out" with meB12 and meFolate.
On another note, I read peroxynitrite destroys NADH, which helps me understand the above regarding the elevated fatty acids. When the methylation cycle is running better, peroxynitrite will reduce, NADH will increase and help present fatty acids to te mitochondria and carnitine, which will also increase due to better methylation, will catalyse beta-oxidation. I am learning more and more how crucial methylation is for sooooo many different crucial functions.
I would prefer carnitine to be formed naturally as methylation comes back on line, since methylation produces carnitine from lysine. I am taking fulvic minerals, which is arguably the best form and balance of minerals for human's. I also take 5,000IU vit D and 1mg vit C per day.
My MD was saying the one-off DMSA gets all the extracellular stuff while the 3 day challenge (with a couple of doses of NAC in between) gives a much better indication. I know there is likely to be quite a lot of stuff there but at the same time, the MD has done hundreds of these profiles (as he does chelation therapy) and has good experience to recognise heavy metal burden.
Your description of "life" resonates with my feelings of life. Trying to push through it all and spend time with others seems like a great idea in theory but when it comes down to it, I take no action and don't really want to...at the same time, knowing it is not the "normal" way to live. Since I have been in this situation from age 8, I never knew any different and thought "it's just me". But now I know it is anything but normal!!
This is from dbkita:
When you say "knocked your socks off" , is that a good thing? (my brother had his knocked off in a car acc. )
Thank you
question about the other form of B12
Hi LynnD, the third form of B12 that you are asking about has several names. It is called Dibencozide, Adenosylcobalamin, and Cobamamide.
This is the Wikipedia entry for it: http://en.wikipedia.org/wiki/Adenosylcobalamin
Freddd refers to it as AB12, "A" (for Adenosyl) + "B12", I think.
Hi LynnD, the third form of B12 that you are asking about has several names. It is called Dibencozide, Adenosylcobalamin, and Cobamamide.
This is the Wikipedia entry for it: http://en.wikipedia.org/wiki/Adenosylcobalamin
Freddd refers to it as AB12, "A" (for Adenosyl) + "B12", I think.
My friend's shoes came off in our car accident. She got out of the car in bare feet, walking on broken glass, put the dangling battery - dripping acid - back into the car, closed the hood, got back into the driver's seat and tried to start the car to drive away. She was in a bit of shock. Anyway that's how I spent my 16th birthday. Fun, fun, fun!
As for the Anabol knocking my socks off, I'm referring to the energy boost it gave. I was taking Source Naturals Dibencozide at about 5mg (half a tablet). I was doing ok on it. I read Freddd's posts about the Anabol and how potent it was so that's why I only took 1/6 of the 10mg capsule. I almost couldn't handle the energy it gave me. I was clearly still quite deficient in adb12 then. Now I'm up to 1/3, sometimes 1/2 of a capsule. If I need an energy boost I'll take extra. Like when I went to the Rush concert earlier this month. I took my regular dose in the morning and then another 1/2 capsule before the show. Got through it with no problems.
As for LCF (carnitine fumarate) I'm not sure it's doing much for me. It makes my husband shaky and he doesn't like that. But I don't notice much of anything with it. When I get my butt in gear I'm going to try ALCAR and see if that does anything different for me.
Oh and I get the Anabol from iherb. It costs a small fortune for shipping and duty, but it gets here in about 2 days which is great!
My metabolic profile showed lots of plasma fatty acids were at the high end. Rich said this was likely due to a lack of NADH which "presents" the fatty acids to the mitochondria. I took 50mg NAD per day and my liver enzymes went through the roof! This is good evidence that B3 does reduce methylation function but I feel it is only of consequence when there is a lack of methylation and possibly not when the MTR enzyme is being "topped-out" with meB12 and meFolate.