Back in the summer, when I started on Fred's protocol, I got what I took to be some start-up symptoms when I added in the mb12 (I'd previously started on the basic vits, minerals, B complex and ab12). The symptoms were a weird sensation in my face and tailbone, which I'd never experienced before. As I continued with the protocol, I became increasingly exhausted and (not normal for me) got sore muscles, neither relieved by potassium or magnesium. I came off that protocol, those effects all went away (the exhaustion and sore muscles took a long time to go) and switched to the SMP. I've had no discernible effects, good or bad, with the SMP so far (this is Week 11). Three weeks ago I considerably increased my intake of green vegetables as part of the Wahls Diet, which also includes onions, hemp milk, nuts, and wild fish (hence high in Omega 3). For the last few days, I've been getting the weird sensation in my face and tailbone again. I'm also exhausted, though that could be from a virus that I caught a week ago. I've got some muscle soreness but that started the day before I started my switch to the Wahls Diet. Does it make any sense that I'm getting what seem to be start-up (or possibly detox) effects at this point in the SMP? I'm assuming a paradoxical folate deficiency caused by the folate in the greens would have kicked in ages ago but if not, would such a thing show up in my Health Diagnostics methylation panel when I get it done?