Severe ME Day of Understanding and Remembrance: Aug. 8, 2017
Determined to paper the Internet with articles about ME, Jody Smith brings some additional focus to Severe Myalgic Encephalomyelitis Day of Understanding and Remembrance on Aug. 8, 2017 ...
Discuss the article on the Forums.

Staph vaccine to treat CFS??

Discussion in 'Alternative Therapies' started by SpecialK82, May 4, 2010.

  1. Jesse2233

    Jesse2233 Senior Member

    Messages:
    1,712
    Likes:
    4,297
    Southern California
    @Hip were you ever able to contact Semenova? Or get a second round of new un-damaged vaccines to test?
     
  2. Hip

    Hip Senior Member

    Messages:
    9,468
    Likes:
    14,980
    @hvac14400 (who is Russian) was able to contact Semenova, and we worked out that the "purified staphylococcal toxoid" vaccine she mentions in her papers is very likely the Russian Staphylococcus toxoid vaccine, non-adsorbed version, made by Medgamal (because Semenova used to work for the research department of Medgamal). Semenova's published studies found that this vaccine seems to be able to boost the immune system against coxsackievirus B infections.


    I did buy a new batch of the Staphylococcus toxoid adsorbed vaccine, and I tried two injections with the new batch, one on 22 May 2017, and another around week later on 30 May 2017. But there was no sign at all of the major improvements that I had obtained previously on some occasions (but not on others) with the older batch of this vaccine.

    So it remains a mystery as to why I got those major improvements on two occasions when injecting the vaccine, but cannot seem to replicate them.

    One possible explanation that I discovered when scrutinizing my drug and supplement diary is that on the two times the vaccine worked and I had major improvements in brain fog and cognition, I had been taking high doses of vitamin D3 (12,500 IU daily). In fact, I had been taking this dose of vitamin D3 for one whole month prior to the two occasions when the vaccine actually worked.

    So I want to test to see if vitamin D3 might be the crucial factor that makes the vaccine work. Some time soon I am going to again load up on the vitamin D3 for one month beforehand (because it takes many weeks of supplementation to raise blood levels of vitamin D), and then try the vaccine again.
     
    Asklipia, Cipher, Abha and 5 others like this.
  3. Jesse2233

    Jesse2233 Senior Member

    Messages:
    1,712
    Likes:
    4,297
    Southern California
    @Hip interesting

    I’ve been wondering about a potential connection between the vaccine’s mechanism of action and the work of Ty Vincent on LDI.

    Is it possible the immune system is being temporarily desensitized to a chronic low level pathogen when the vaccine is administered? And if so, might a more extended recovery in some cases call for several different antigens to be used if there are different pathogens requiring immune desensitization?
     
  4. Hip

    Hip Senior Member

    Messages:
    9,468
    Likes:
    14,980
    I have never looked into LDI in any depth, so I don't know much about it. I am not sure if the vaccine might possess any immune desensitizing effects.

    Possible mechanisms of action of the original Staphypan Staphylococcus vaccine include:
    • Alpha toxin is a strong IL-17 and Th17 inducer. 1 2
    • Alpha toxin increases nitric oxide (which is antiviral). 1
    • Alpha toxin corrects coxsackievirus B-induced immunodeficiency (Semenova papers).
    • Staphylococcus toxoid improves diabetes. Staphylococcus toxoid vaccine was used as a treatment as early as the 1930s, and this 1936 study found that Staphylococcus toxoid vaccine improved diabetes (diabetes is also linked to coxsackievirus B infection).
    • Alpha toxin interacts with ADAM10 receptor (also called CDw156 or CD156c ). 1
    • Enterotoxin A binds to the major histocompatibility complex class II (MHC II), which is the antigen-presenting mechanism of cells. 1
    • Enterotoxin B binds to the CD28 receptor, and this receptor has been linked to autoimmune disease (CD28 controls differentiation of regulatory T-cells, which play a central role in maintaining immune self-tolerance).
    • Staphylococcus antigens may induce cell-mediated immunity. 1
    Nobody seems to know why the Staphypan Staphylococcus vaccine works for ME/CFS, including Prof Gottfries and his team. Various speculative mechanisms have been discussed in earlier posts in this thread (there is an index to these posts here).
     
  5. Cipher

    Cipher

    Messages:
    4
    Likes:
    5
    Did you try the adsorbed or non-adsorbed version, and for how long did you try it?

    What type of mental side effects did you experience?

    :) *fingers crossed*
     
  6. Hip

    Hip Senior Member

    Messages:
    9,468
    Likes:
    14,980
    Some very mild psychosis symptoms — symptoms which I do get now and then anyway (I developed some intermittent mild psychosis after a viral brain infection 12 years ago). Although I was originally fine with the vaccine, more recently I am finding that the vaccine sometimes triggers mild psychosis symptoms, starting one or two days after an injection, and lasting for one or two days. Nothing serious, but certainly unpleasant.
     
    Last edited: Nov 24, 2017
  7. Isaiah 58:11

    Isaiah 58:11

    Messages:
    93
    Likes:
    135
    A Sun-Scorched Land
    I am sure this sounds stupid, but I think Staph infections may be helping me recover; they seem to be modulating my immune system in a similar way as the vaccines did for others. My most recent was 6-8 weeks ago and after I started antibiotics my lungs hurt, which I thought was odd. Then, over the next week or two, I developed vertigo like I had at onset (and after my first major Staph infection 12ish years into ME), a sore throat, sore Lymph nodes, etc. basically all the symptoms I had on onset that I lost as I progressed in severity.

    Now, I can tell that something has definitely changed! I have headaches again (I used to the first years after onset) and have ridden my bike around the block twice in the past week. I have done 60 seconds of 5-10 lb weight lifting a number of times without acute crisis or subsequent crash. I haven't noticed actually having any more baseline energy yet, but I can tell that something major has shifted and the improvements have continued after the cessation of antibiotics.
     
    Jesse2233 likes this.
  8. Jesse2233

    Jesse2233 Senior Member

    Messages:
    1,712
    Likes:
    4,297
    Southern California
    @Isaiah 58:11 that is fascinating! I think there's some really important things to learn in experiences like yours. I've noticed similar things and wondered if it's an IRIS response akin to what HIV patients experience when starting HART treatment.

    Keep us updated.
     
    Isaiah 58:11 likes this.
  9. Hip

    Hip Senior Member

    Messages:
    9,468
    Likes:
    14,980
    That's an interesting observation; were these infections you experienced diagnosed by your doctor as staphylococcal?

    When first reading about the Staphylococcus vaccine treatment for ME/CFS, it did occur to me that people who naturally have Staphylococcus infection in their body (I have quite a large Staphylococcus aureus population in my colon) might be protected from developing the more severe forms of ME/CFS.

    If we assume that the alpha toxoid in the vaccine has a positive effect for ME/CFS, then natural chronic Staphylococcus infections in the body, which will produce alpha toxin, may confer some benefits for the ME/CFS patient.
     
  10. Isaiah 58:11

    Isaiah 58:11

    Messages:
    93
    Likes:
    135
    A Sun-Scorched Land
    The initial ones were. This last one I just sent photos because the sores occurred in some of the exact same spots, like there is a reservoir in that location.

    I first really wondered what was going on because a week or two after the antibiotics cleared it, the sore areas started getting pink and puffy all over again, with the zone expanding and instead of having to call the doctor because it got bad again, they just went away! (This has never happened before.) My immune system just gave them the smackdown! I have been able to shave regularly and am no longer using Hibclens and alcohol razor soaks.
     
  11. CaptainA

    CaptainA

    Messages:
    71
    Likes:
    120
    So I just wasn't getting enough from the treatment after 6 months so I stopped. At the end I was injecting 1ml every two weeks so 2ml/mo. After injections I got a good reaction that would last about 24-48hrs but that was it. I would like to note that not much has moved the needle for me anyways. I seem to only get herxing from some treatments and not any good outcomes. I'm also a functional ME/CFSer as I'm able to work at least 3 hours a day so I may be in some weird sub group. If another version of this vaccine comes out I would interested in giving it another go.
     
    Cipher, Abha, panckage and 1 other person like this.

See more popular forum discussions.

Share This Page