Professor & patients' paper on the solvable biological challenge of ME/CFS: reader-friendly version
Simon McGrath provides a patient-friendly version of a peer-reviewed paper which highlights some of the most promising biomedical research on ME/CFS ...
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Staph vaccine to treat CFS??

Discussion in 'Latest ME/CFS Research' started by SpecialK82, May 4, 2010.

  1. lansbergen

    lansbergen Senior Member

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    If mercury is forbidden what adjuvant would you use?
     
  2. lansbergen

    lansbergen Senior Member

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    http://www.fiercebiotech.com/story/nabi-s-staphvax-fails-late-stage-study-for-infections/2005-11-01

    Nabi's StaphVax fails late-stage study for infections


    October 31, 2005

    Nabi Biopharmaceuticals' share price got hammered this morning after the biotech announced that StaphVax failed to reduce infections among kidney patients, flunking a late stage trial. The 3,600 patients in the study demonstrated no reduction in Staphylococcus aureus infections. The biotech swiftly dropped an application for European approval and ended development of a similar staph vaccine. Nabi's stock plunged 67 percent on the news.
     
  3. Ninan

    Ninan Senior Member

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    Don't know but the clinic obviously does.
     
  4. mellster

    mellster Marco

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    San Francisco
    Thanks - crap, was my article that old? It had no year listed so I assumed it was 2013. Doesn't change the fact that they are continuing to try new formulations and change target groups. Same as with oncology, 4 out of 5 fail but progress is inevitable. I found an article discussing the StaphVax failure, incl. further studies for possible subgroups:
    http://www.medscape.com/viewarticle/805089
     
  5. bertiedog

    bertiedog Senior Member

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    South East England, UK
    I was tested at the Breakspear 2 years ago for evidence of Staph as well as a viral panel and Chlamydia Pneumonia. I was negative for Staph ad Chlamydia and EBV but positive for 5 or 6 Herpes type viruses including Cytomegalovirus. Since then I have taken Immunovir and Artesunate with no change to my health or to the ore or less permanent inflamed throat I have had for over 13 years.

    Thanks to testing on my Autonomic System though they found one year later that I was more than 50% short of oxygen in my cells and Dr Munro recommended I use an oxygen concentrator for up to 3 times daily and since then I have done this to great effect.

    Just wish I knew for sure why I have such low oxygen in my cells.

    Pam
     
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  6. Ninan

    Ninan Senior Member

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    Nah, I wish! I felt great for one month after the swine flu shot so I'm pretty sure this would help too.
     
  7. lansbergen

    lansbergen Senior Member

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    The clinic that can not find a replacement?
     
  8. Ninan

    Ninan Senior Member

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    As I wrote above: They searched "the whole western world". Nothing.
     
  9. lansbergen

    lansbergen Senior Member

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    How does that show they obviously know what adjuvant to use as a replacement for mercury?
     
  10. Ninan

    Ninan Senior Member

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    It doesn't, I misread your post. But that is obviously not an issue since they say they can make a vaccine without mercury. The company which produced the original vaccine could too, they just thought it was too expensive. The problem isn't how, it's money. And yes, the clinic is the Gottfries clinic outside Gothenburg.
     
    Last edited: Dec 8, 2013
  11. Hip

    Hip Senior Member

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    The $900,000 you say is required to develop a new mercury free version of the Staphylococcus vaccine. However, what about just restarting production of the original mercury containing Staphylococcus vaccine (in a country where it is legal to do this)? Presumably that would not cost much.

    I think the important thing would be to perform some proper studies on this Staphylococcus vaccine, and publish data on its efficacy for ME/CFS. I don't think there is any data, as far as I am aware, except anecdotal info.

    Once there is a published a study on the efficacy of Staphylococcus (and assuming it does have good efficacy), then you can consider creating a mercury free vaccine. And if a restarted production of the mercury containing vaccine was really helping thousands of ME/CFS patients to get significantly better, I don't think you would have any difficulty in raising the $900,000.

    Only recently nearly half a $million was raised in just 90 days by crowdsourcing from the ME/CFS community to perform a rituximab trial. I think the money would be raised if the data of efficacy was there.
     
    Last edited: Dec 8, 2013
  12. Hip

    Hip Senior Member

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    Note that mercury in vaccines is not an adjuvant, but a preservative. Aluminum hydroxide is used as the adjuvant in many vaccines.

    The function of an adjuvant is to boost the immune system when the vaccine is given; this boost is necessary in order for immune system to be properly trained by the antigen present in the vaccine.
     
    Last edited: Nov 23, 2015
  13. Hip

    Hip Senior Member

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    StaphVax does not appear to be a Staphylococcus toxoid vaccine, which I think is what you may need for treating ME/CFS. The Staphylococcus toxoid vaccine contains a weakened form of a toxin made by Staphylococcus called alpha toxin. When you get this toxoid vaccination that contains weakened alpha toxin, it trains your immune system to make antibodies against alpha toxin (but not against the Staphylococcus bacterium itself).

    The idea is that the alpha toxin secreted by the Staphylococcus bacteria creates many of the major problems of a Staphylococcus infection, so if the immune system is trained to make neutralizing antibodies against alpha toxin, this will greatly reduce the impact of a Staphylococcus infection.

    Just how alpha toxin might act as an immunomodulator that benefits ME/CFS, I do not know.
     
    Last edited: Nov 23, 2015
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  14. Ninan

    Ninan Senior Member

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    The studies were published years ago, it's all there:

    http://www.gottfriesclinic.com/forskning_artiklar.html
     
  15. lansbergen

    lansbergen Senior Member

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    In animals vaccines it was called an adjuvant.
     
  16. Ninan

    Ninan Senior Member

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    In this case it was a preservative. (My sources are in Swedish, that's why I don't share them here.)
     
  17. Hip

    Hip Senior Member

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    Thanks very much for that link. In fact, I think have actually seen one or two of those studies before.

    Here are the study abstracts:

    Well, I think that there is enough clinical evidence there to start money raising campaign. It might be an idea to initially contact Maria Gjerpe in Normway, who is the doctor who has ME/CFS herself that was able to raise ½ $million by crowdfunding for a rituximab trial, and ask her for general advice, and what she did to be so successful in her campaign.
     
    Last edited: Jul 1, 2016
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  18. Hip

    Hip Senior Member

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    @Ninan

    Do you know much about the history of using Staphylococcus toxoid vaccine to treat ME/CFS? Was this treatment mainly done in Sweden, and mainly done under the monitoring of Professor Gottfries? Or did it also occur in other countries, and by other researchers? I have certainly not heard of it being available in the UK.

    And what happened to all the ME/CFS patients in Sweden who were taking Staphylococcus toxoid vaccine, and became healthy enough to go back to work, when the vaccine was withdrawn, as a result of the Swedish FDA ban, due to its mercury preservative?
     
  19. Ninan

    Ninan Senior Member

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    Thanks for the links! I haven't read them.

    I'm a journalist myself and have worked with campaigns before. We are a few people thinking about this but we're all pretty, very, sick. I'm normally a 0-1, 2 with a strange side effect of Neurontin.

    Maria had the novelity thing on her side -- it was news. This is not really. And I think a lot of people are afraid of vaccines after all the talk of people getting sick from them.

    But yes. It can probably be done. Maybe we can pick up the commitment to rituximab -- nothing will happen there in years. Someone should talk to Olof Zachrisson at Gottfries Clinic. Who happens to be one of my doctors. I can ask him how far they've come and what they need and get back to you.
     
  20. Ninan

    Ninan Senior Member

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    I'm pretty sure it was only used here. And the ban only included new patients. I think the ones already using it could go on. But now it doesn't exist anymore, so I guess they had to quit. I can try to get some answers and get back to you. (We should have this conversation under another headline.)
     

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