The Journal of Physiology: August 1st 2012: http://jp.physoc.org/content/590/15/3413.full Standing up for exercise: should deconditioning be medicalized? Michael J. Joyner1 'In this issue of The Journal of Physiology, Shibata and colleagues (2012) from the Levine lab demonstrate that 3 months of exercise training can reverse or improve many of the signs and symptoms of a type of orthostatic intolerance known as the postural orthostatic tachycardia syndrome (POTS). This syndrome is marked by an excessive heart rate response to standing, a high heart rate response to a given level of exercise, and (among other things) reduced exercise capacity. While a number of pathophysiological explanations for POTS exist, over the last 5–10 years several labs have noted that the pathophysiology of POTS bears a striking resemblance to extreme forms of deconditioning such as prolonged bed rest (Joyner & Masuki, 2008)...' Was featured by the Daily Mail yesterday which referred initially to CFS/ME but later removed this reference, although POTS remains: A case of lazyitis? Not bothering to exercise 'should be treated as a medical condition' Read more: http://www.dailymail.co.uk/health/article-2188163/A-case-lazyitis-Not-bothering-exercise-treated-medical-condition.html#ixzz23ghPqsfY 'Several chronic medical conditions are associated with poor capacity to exercise, including postural orthostatic tachycardia syndrome better known as POTS, a syndrome marked by an excessive heart rate and flu-like symptoms when standing or a given level of exercise. Too often, medication rather than progressive exercise is prescribed, Dr. Joyner said. He noted that a study from the University of Texas Southwestern Medical Center found that three months of exercise training can reverse or improve many POTS symptoms...'