Hi, Many of us have tried regular antidepressants at one time or another but many of us cfsers seem to get side effects from them, more so then the general public it seems. On paper it seems that if a substance can increase our neurotransmitters then it could or should not only help improve mood and depression but also cognitive energy and concentration as well as memory etc etc. Many have turned to more natural substances like 5 htp, tryptophan or sAME as an alternative to an antidepressant and it seems that they dont have anywhere near the same side effects. St johns wort is something i havent heard many people say they have used on here. Its been a long time since i used SJW and it was pre cfs and i used it as more of an energy boost for sport then anything else and from memory it worked ok. But i would like to hear others experiences with it, any side effects etc and if it not only helped mood but cognitive issues etc. The above substances i typed enhance serotonin but i believe SJW enhances serotonin, noradrenaline and dopamine, a triple whammy. Also im not against antidepressants but looking for alternatives that could help us with our cognitive issues including mood, memory, concentration, anxiety etc etc. So im interested to hear what people have to say. cheers!!!