NOTE: PLEASE DON'T POST ADVICE ON IMPROVING MY CURRENT METHYLATION PROTOCOL HERE-- JUST ON THE GENE TEST QUESTION I thought I'd get the collective take on whether any of you have found the genomic testing for methylation defects worthwhile. Context: I know I have at leas one methylation defect MTHFR C677T- this test was covered by insurance because the defect affects both heart disease and pregnancy. It's "accepted" for clinical use. My CFS doc put me on Metafolin and suggested I gradually ramp up this and methylcobalamin. I've been taking the Metafolin for about 5 months with no noticeable difference, currently 800mcg twice a day. I was not as consistent about the B-12 until recently as I've been reading more on this forum from Rich and Fredd and others. Having increased my methylcobalamin 5mg x 4 a day I have a noticeable increase in energy, but my brain fog remains untouched. My guess is that I have defects in other parts of the cycle and that the Metafolin and methylcobalamin is only filling one slot of a more problematic cycle. I've 30 years of "experimenting" with CFS protocols! I really hate the hit or miss nature of putting time and energy and money into another new protocol without some kind of definite information. I thought the gene testing was outlandishly expensive last time I had looked, but Yasko's site has a Comprehensive Methylation Panel with Methylation Pathway Analysis for $495. This is less than I remember, but still a chunk of change if the the chance of impacting symptoms is still vague. In other words, just cheap enough to be tempting, but I've spent lots of money on CFS treatment and I'm jaded. So, Question: Those of you who have gotten the testing, has it paid off? I suspect that there is a wealth of advice folks might have on how I could do what I'm already doing about methylation much better. Could you please NOT POST THAT HERE. I'll start another thread with "Why is this not working so well?" For your advice. I'd like to keep this thread clear on the Panel question.