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spironolactone vs. cfids (autism) any opinions?

Discussion in 'General Treatment' started by Navid, Feb 14, 2010.

  1. Navid

    Navid Senior Member

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    **** i read this on another group that discusses xmrv and autism....wondering what people here know and or think about this drug as a potential treatment for cfids.

    thanks, lisa


    Some Defeat Autism Now doctors have been using spironolactone on autistic
    children for years. It is primarily a diuretic drug, but it has strong
    anti-inflamatory properties as well, especially on the brain, and it is potent
    anti-androgen as well. here is a paper related to spironolactone:

    http://www.icdrc.org/documents/Bradstreet Spironolactone Author Copy.pdf


    > Link between autism and abnormal blood-vessel function and oxidative stress
    >
    > http://www.eurekalert.org/pub_releases/2006-08/uops-lba081506.php
    >
    > Practio discusses a link between autism and abnormal blood-vessel function and
    oxidative stress
    >
    > Quote "Compared with controls, children with autism had significantly higher
    urinary levels of isoprostane "[a biomarker for oxidative stress ]
    >
    > Pratico and colleagues measured levels of isoprostane, the chemical byproduct
    of free radicals attacking fat cells and found that patients with autism possess
    nearly double the level of oxidative stress than that measured in healthy
    controls.
    >
    > Pratico's team measured isoprostane, a biomarker for oxidative stress;
    thromboxane, an index of platelet activation; and prostacyclin, a measure of
    blood vessel activation in the samples. "This study represents the first
    observation that the rates of thromboxane and prostacyclin synthesis are both
    not only significantly increased in autism, but are closely correlated with the
    rate of oxidative stress," says Pratico. Compared with controls, children with
    autism had significantly higher urinary levels of isoprostane, thromboxone, and
    prostacyclin.
    >
    > In general, it is known that abnormalities in blood vessels can be clinically
    reflected by an abnormal blood flow," says Pratico. "In this regard, it is
    interesting that earlier neuroimaging studies of autistic children have
    demonstrated a reduced amount of blood reaching the brain. Shedding more light
    on the relationship of oxidative stress and blood-vessel health to the pathology
    of autism could lead to improvements in therapy."
    >
     
  2. Tammie

    Tammie Senior Member

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    Woodridge, IL
    well, there are definitely similarities between autsim and CFS, but I know that I, and many others with CFS, already have problems with needing to urinate WAY too often, so something that acts as a diuretic could be REALLY bad for us
     
  3. faith.hope.love

    faith.hope.love Senior Member

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    I have taken low dose spironolactone in the past for PCOS. I now take drosperinone in my birth control pills (Yasmin), it's comparable to 25mg Spiro. I have a LOT of water retention without it. My face, especially, gets very puffy. It definitely controls my PCOS symptoms, which makes me feel better as a whole, but I haven't noticed any effect on my CFIDS symptoms. Well, I think endocrine dysfunction IS a part of CFIDS, so if you look at it that way, I guess it does really help.
     

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