Hi all, I've had incredible success over the past year or so by supporting methylation with folate, mb12, etc. However, taking folate and/or mb12 causes my muscles (and esp shoulders) to become extremely sore and weak. I'm a pretty strong guy normally but the folate and mb12 completely changes that. Oddly enough, my endurance capacity has gone up dramatically. I've tried high doses of potassium gluconate daily with little to no change.