I've been on the Rich von K simplified protocol for 5 weeks (very beneficial). Now I want to get a bit more detailed & methodical. I've got my 23andme results, and have been through the Yasko book & Heartfixer site to determine what supps/diet changes to make, as workarounds for my SNPs. I've made a list of things to introduce - in 'Yasko order' (e.g. ACAT first). Questions: * So now I start introducing those things gradually, right? * Do I need every supplement for each SNP? For example ACAT needs Adenosyl B12, other forms of B12, low dose vit E succinate, a little Actofolate, CQ10, lactoferrin. SAMe, bile salts, GSH, curcumin, quercetin. For the sake of my wallet (& simplicity) could I (for example) forget about the quercetin, lactoferrin, bile salts and SAMe? * Typically, how long might I wait before I notice anything? * When do I move on to the next SNP? * Apart from my MAO-A (which is a simple +), all my SNPs are +/-. Most of the Yasko & Heartfixer recommendations are for people with +/+ SNPs. So do I just water down the prescriptions somewhat - take less? Any advice appreciated. Thanks, John FYI, I have these SNPs: ACAT, CBS, MTHFR, MTR, MTRR, BHMT, COMT, VDR (all +/-), and MAO-A (+).