Hi Freddd, I haven't figured out the metafolin yet. On a normal day lately, just 800mcg. I have gone up to 12800mcg in the past though. I got some neurologocial indications that this did something but I don't know what. It was impossible to sustain at that level for more than a day, due to the additives in the metafolin being tough on the stomach at that level. I'm kind of frustrated that I never managed to figure out if folate is a big issue for me. I had one flukey good day when I went 2 whole days without food folate (no vegetables etc) but was not able to duplicate that, even with a schedule of 16 metafolin tabs one day and no food folate the next. If there was a benefit, it only seemed to occur after two full days without food folate, and I have no viable way of doing that.