First of all, I just want to say that I realize that no one is going to be able to figure all of this out for me, and that I am going to have to do a lot of my own footwork. Honestly, while it'd be awesome if someone could give me all the answers, even if it were possible, I wouldn't feel right expecting that from them, unless they were a doctor, being paid for their services. I say that because this methylation stuff has the potential to be so thick, especially the more a person is affected by it, it really takes a lot of time, thought, and energy to properly figure out. All that said, if you could just take a quick look at my list of mutations, and offer some brief insight, suggestions, what have you, that would be great! Here they are: COMT V158M +/- COMT H62H +/- COMT P199P +/- VDR Taq +/+ MAO A R297R +/+ MTHFR C677T +/+ MTRR K350A +/+ BHMT 02 +/- BHMT 08 +/- Tested via 23andMe. Raw data ran through Genetic Genie. I suffer from Lyme and a few coinfections, leaky gut, and multiple chemical sensitivity (I really seem to have a problem with salicylates, phenols, and histamine). I believe sulfur/ammonia is a problem as well, as large amounts of meat make me feel bad, to put it simply. My reactions to these problem items range from the mental and physical - difficulty thinking, aches and pains, thirst, runny nose, dry, watery, irritated eyes. Mornings after reactions, I wake very dehydrated, and with blurry vision. Because of these things, my diet is rather limited. I mostly eat chicken, fish, eggs, broccoli, asparagus, avocado, healthy fats and oils like coconut and avocado, ghee, nuts occasionally, green beans, cabbage, zucchini, and a few prepackaged mixes of veggies. Not much fruit, because I am on what's known as a ketogenic diet, due to my issues with sugar. I could probably eat some small amounts, but being that there is a carb maximum to maintain ketosis, sticking with vegetables means I am able to eat more/get more nutrition. One medium-sized apple, or half a pound of steamed broccoli with some oil? Call me crazy, but give me the broccoli. I would like to be on a "regular" diet, but I have terrible reactions to high sugar, carb items, even starchier vegetables. I do not know if it is fungal, leaky gut, a combination, but I can't. Now, I realize that certain aspects of a high fat, high protein diet are bad, and that a number of the foods I am eating are high in chemicals I am sensitive to and/or create them as byproducts, but I just have no other options. It is a case of if I eat X food it is bad for Y condition. If I were to adhere to all of the recommended diets for each of my conditions, I wouldn't be able to eat at all. For years, I half starved myself to death, avoiding certain foods, because of some of my health conditions. For the first time since 2013, I have been able to get more than 2000 calories a day, thanks to being on a ketogenic diet, and without feeling like the foods are setting me back, aside from the chemical reactions. My goal is to get back to a more traditional, yet still healthy, diet. But, I can't just yet. That said, I would really like to work on the methylation issues, supporting for my particular mutations, while adding in a few more foods so that I can better rotate the ones that I have trouble with to minimize chemical sensitivities. I figure that if I start to get the methylation cycle functioning properly, these chemicals will no longer be as much of a problem. I have other issues to work on as well, which I am/have plans to once I get the methylation, diet, gut support, and detox pathways in order. Lastly, I realize that this is kind of a lot to throw at people, I'm a total stranger to you, you all have your own lives, etc. I intended for it to be as short as possible. I tried. This is the bare minimum. I am not asking for cures, just some quick thoughts and suggestions. I have done a lot of my own research. The popular mthfr websites, heartfixer, etc. I have other health forums I am receiving help from. BUT.. I've been told that this is where the methylation experts reside, so here I am. Again, just a quick comment, if you can manage. Really appreciated. Thanks! Also, methylation-related supplements: FOLAPRO - 800mcg Adeno/Hydroxy (b12 50/50 combination) - 2000mcg GABA 500mg three times daily Seeking Health's multivitamin TMG, but stopped due to reactions. I have read that some are sensitive to this, depending on mutations. Powdeded yucca for ammonia. I have noticed headaches from the folate and b12. I have other stuff planned to be taken, but wanna see if any of that aligns with what is suggested here. Again, IF you can offer a little help, thanks. If not, understandable. Will check back after work tonight.