Dolphin kindly suggested that I repost this as a separate topic for discussion. I'd initially posted this on the thread discussing comments made by members of the biopsychosocial school (Peter White specifically) which may provide a clearer insight into their attitudes to ME/CFS. These are excerpts from a presentation given by Peter white in 2009 : This is essentially the core of the biopsychosocial model of ME/CFS. No physical abnormalities are found (the doctor cannot explain the symptoms), there is (by some accounts) high co-morbidity of depression, ergo self reported symptoms have no physical basis and arise as a consequence of mental distress. A 'classic' case of a psychosomatic illness. Except 'psychosomatic' as used today is a corruption of the initial intent of those psychiatrists that first described the phenomenon. This paper is from the journal Biopsychosocial Medicine : Symptoms of somatization as a rapid screening tool for mitochondrial dysfunction in depression Far from a multitude of vague and varying symptoms being highly suggestive of a psychosomatic disorder as is often stated as an accepted fact in some quarters, somatic symptoms occurring in conjunction with depression is actually highly suggestive of a mitochondrial disorder. The authors suggest that a small subset of questions from the Karolinska Scales of Personality questionnaire can be used to effectively distinguish those patients whose depression, as well as somatic symptoms, are likely to have arisen from a mitochondrial disorder. Here are the six KSP questions used as the screening tool : If you have co-morbid depression and score two or more of these items as Applies Completely the authors suggest that you are likely to have a mitochondrial disorder. http://www.bpsmedicine.com/content/2/1/7 Perhaps Peter White doesn't subscribe to 'Biopsychosocial Medicine'?