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Somatic mutations in clonally expanded cytotoxic T lymphocytes in patients with newly diagnosed RA

Discussion in 'Other Health News and Research' started by AndyPR, Aug 30, 2017.

  1. AndyPR

    AndyPR Tired Sam ate all the cookies!

    Thought this might be interesting, especially in light of Mark Davis' recent talk on T cells. Please note though that I have no real understanding of what I'm reading here. :)
    Open access at https://www.nature.com/articles/ncomms15869
     
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  2. Philipp

    Philipp

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    Serious question: What does the 'somatic' modifier do there? Is it to distinguish from 'genetic' or something (i.e., a somatic mutation being something that has 'manifested as tissue' or whatever)?
     
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  3. melihtas

    melihtas Senior Member

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    Istanbul Turkey
    Wikipedia
     
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  4. lansbergen

    lansbergen Senior Member

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    It is an aquired mutation not present in every cell.
     
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  5. RogerBlack

    RogerBlack Senior Member

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    However certain cells in the body (t-cells) for example, are cloned from one prototype cell - this is how much of the immune system that reacts to specific things works.

    So, a mutation can be significant to the patient, because it can end up massively multiplied.
    This happens in cancer, though in that case, the multiplication is not intended by the body, which causes seperate issues.
     
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  6. melihtas

    melihtas Senior Member

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    Istanbul Turkey
    As far as I understand, according to the paper, the mutations are not present in the original t cells, they are created during clonal expansion, so, something in the serum must be causing it like Ron Davis said.

     

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