Choline on the Brain? A Guide to Choline in Chronic Fatigue Syndrome
http://phoenixrising.me/research-2/the-brain-in-chronic-fatigue-syndrome-mecfs/choline-on-the-brain-a-guide-to-choline-in-chronic-fatigue-syndrome-by-cort-johnson-aug-2005
Discuss the article on the Forums.

Somatic mutations in clonally expanded cytotoxic T lymphocytes in patients with newly diagnosed RA

Discussion in 'Other Health News and Research' started by AndyPR, Aug 30, 2017.

  1. AndyPR

    AndyPR Senior Member

    Thought this might be interesting, especially in light of Mark Davis' recent talk on T cells. Please note though that I have no real understanding of what I'm reading here. :)
    Open access at https://www.nature.com/articles/ncomms15869
     
    dangermouse, nandixon, Aroa and 4 others like this.
  2. Philipp

    Philipp

    Messages:
    80
    Likes:
    509
    Serious question: What does the 'somatic' modifier do there? Is it to distinguish from 'genetic' or something (i.e., a somatic mutation being something that has 'manifested as tissue' or whatever)?
     
    Aroa and AndyPR like this.
  3. melihtas

    melihtas Senior Member

    Messages:
    123
    Likes:
    351
    Istanbul Turkey
    Wikipedia
     
    Valentijn, Aroa, AndyPR and 1 other person like this.
  4. lansbergen

    lansbergen Senior Member

    Messages:
    2,511
    Likes:
    2,722
    It is an aquired mutation not present in every cell.
     
    RogerBlack, Aroa, AndyPR and 2 others like this.
  5. RogerBlack

    RogerBlack Senior Member

    Messages:
    897
    Likes:
    2,902
    However certain cells in the body (t-cells) for example, are cloned from one prototype cell - this is how much of the immune system that reacts to specific things works.

    So, a mutation can be significant to the patient, because it can end up massively multiplied.
    This happens in cancer, though in that case, the multiplication is not intended by the body, which causes seperate issues.
     
    Valentijn likes this.
  6. melihtas

    melihtas Senior Member

    Messages:
    123
    Likes:
    351
    Istanbul Turkey
    As far as I understand, according to the paper, the mutations are not present in the original t cells, they are created during clonal expansion, so, something in the serum must be causing it like Ron Davis said.

     

See more popular forum discussions.

Share This Page