The power and pitfalls of omics part 2: epigenomics, transcriptomics and ME/CFS
Simon McGrath concludes his blog about the remarkable Prof George Davey Smith's smart ideas for understanding diseases, which may soon be applied to ME/CFS.
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Solve webinar today, 19 Nov: "Post-Exertion Malaise: The Intersection of Biology and Behavior"

Discussion in 'Upcoming ME/CFS Events' started by Sasha, Nov 19, 2015.

  1. Sasha

    Sasha Fine, thank you

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    More details here.

    It's 6-7pm GMT - I can't see what time in the US/elsewhere.

    You need to pre-register.

    I'll be out so I'll miss this but I think they put them up on YouTube later (?).
     
    Mij, waiting, Valentijn and 2 others like this.
  2. Sasha

    Sasha Fine, thank you

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    If you register, you can email questions in advance for Dr Cook.
     
  3. duncan

    duncan Senior Member

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    The intersection of biology and behavior? Not biology and activity, or biology and exertion?

    Behavior?

    Little alarm bells ringing in my ears.....
     
    MeSci, geraldt52 and jimells like this.
  4. Sasha

    Sasha Fine, thank you

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    Indeed, but if you read the blurb, it doesn't sound like a 'behavioural' approach.

    I guess we'll see.
     
    duncan likes this.
  5. duncan

    duncan Senior Member

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    The "B" word looks better when you spell it in English vs New Jersey (he pursued his post-doctoral training in NJ): behaviour vs. behavior.

    Downton Abbey vs The Sopranos.

    Darwin vs Snookie.

    House meets....Well, House satisfies both backgrounds technically, I suppose.

    All silliness aside, I know it is an indictment against my character that I distrust an entire discipline. After all, there are individuals like Lenny Jason and Fallon (I add his name begrudgingly).

    I suppose.
     
    Sasha likes this.
  6. Valentijn

    Valentijn The Diabolic Logic

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    My gist is that he's more looking into the cognitive effects of exercise than the psychological side. But that's often classified as being a psychological or neuropsychological area.

    And his general approach to ME/CFS seems to be that the biology causes the behavior, not vice versa. Which makes sense in the context of his studies where such testing is done after the CPET. Might tie in pretty well with what the Lights have been doing.
     
    Mij, Woolie, Sasha and 1 other person like this.
  7. SOC

    SOC

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    NHS vs NIH
    SW vs Francis Collins
    Peter White vs Ian Lipkin
    Queen Mary University London vs Columbia University
    Oxford University vs Stanford University
    Esther Crawley vs Nancy Klimas
    Rod Liddle vs David Tuller
    Ben Goldacre vs James Coyne

    Wait... did I get that backwards? :p
     
    ahimsa, Countrygirl, Woolie and 6 others like this.
  8. Sasha

    Sasha Fine, thank you

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  9. duncan

    duncan Senior Member

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    I was just being silly, poking at my home state with a little self-deprecating humor.

    What has been happening in the name of psychiatry - or at least what some individuals have done under its banner to people with ME and Lyme and many other diseases - is an international travesty.

    And my concerns may not even apply to this man.
     
    ahimsa, BurnA, Sasha and 1 other person like this.
  10. Sasha

    Sasha Fine, thank you

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    A little bump for this... starts in just under an hour.
     
    Zeno likes this.
  11. Sasha

    Sasha Fine, thank you

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    Anybody watch it?
     
  12. waiting

    waiting Senior Member

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    Yes, I thought his presentation was excellent. It's worth the watch once they put it up on their YouTube channel.

    Some excellent, illuminating graphs of controls vs patients -- think the Lights' past gene expression studies.

    Did you see it, @Sasha?
     
    Valentijn and Sasha like this.
  13. Sasha

    Sasha Fine, thank you

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    That's good to know!

    I had to go offline so I missed it but I look forward to seeing it on YouTube.
     
    waiting likes this.
  14. Bob

    Bob

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    England (south coast)
  15. duncan

    duncan Senior Member

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    Seeing as how I was so quick to post about my concerns, I think I should volunteer that after watching the clip, I came away with a different opinion. I feel he says some good things. I think it is well worth the watch (close to an hour).

    I want to see it again. He compares gene expression with symptoms, and on the surface it sounds good. I don't know anything about gene expression, though. Cortisol receptors and three others - what are the implications of the four gene expressions he selected?

    He actually warns that exercise may be dangerous to us - I was floored.

    Again, not sure why he selected the four gene expressions he did - or what their significance is. Also, he tries to point out that symptomology is a very individual thing with PWME. Of course, he is spot on with that. Still, this was after he shows in pooled data how abnormal our scores are from controls. In the process, I wonder if he undermines the impact of the pooled data results.

    Anyway, I went in prepared to dislike this guy. I came way with this sense he deserves a closer look.
     
    ahmo, Keela Too, Sean and 7 others like this.
  16. Sasha

    Sasha Fine, thank you

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    Thanks, @duncan - it's great to see someone who raises a concern about something being fair enough to come back and say that things were actually OK!
     
    MeSci and duncan like this.

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