Discussion in 'Latest ME/CFS Research' started by AndyPR, Jan 21, 2017.
Someone tell me why this ISN'T a diagnostic test?
Presumably because they have only tested one patient who differed from one normal in one respect. The next patient might not differ or might differ in another respect. A diagnostic test needs to show a consistent pattern.
There also need to be enough patients to have some statistical surety, comparison with likely alternate diagnoses, and a measure of specificity and sensitivity (95% or better is preferred, but sometimes this is relaxed if no other test exists). There are other potential tests being looked at, but none meet the full criteria. Of course, you then have to publish the findings.
The researchers seem to be new to ME/CFS.
Exact What I was thinking
Wouldn't you need a control group with similar levels of activity? Like super sedentary or something?
The proposed study looks interesting. They have not claimed the single case provides a diagnostic test, it is simply a starting point of interest.
I assume they will use matched sedentary controls. Possibly also compare with people with other chronic fatiguing illnesses like MS.
There's a long way to go, but I'm glad they are trying. The more interesting leads are followed up, the better chance of useful discoveries being made.
As I read it, this is a funded piece of research that is happening.It will now test the hypothesis formulated from its initial single patient comparison. It may result in a diagnostic test, a step towards one, or at least some advance in knowledge. Sounds great to me.
Always. Wish all researchers would use sedentary controls.
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