bertiedog
Senior Member
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- South East England, UK
On checking emails today the one from this group came through and I thought this one in particular looked very interesting.
Biomarkers for initiation (infection) and metabolic derangement in ME/CFS
A project summary as written by Drs. Blomberg, Bergquist, Gottfries, and Zachrisson:
Our working hypothesis of ME/CFS pathogenesis is that a person predisposed for ME through genetics and previous antigen exposure is infected with a microbe prone to elicit ME. These microbial antigens have epitopes which cross-react with self-epitopes. An (auto)immune response to this microbe which bypasses tolerance mechanisms is elicited. The cross-reactive immune response, e.g. autoantibodies, is directed against molecules involved in energy metabolism, hormonal regulation and, possibly, specific portions of the brain. In short, “infection elicited autoimmunometabolic dysfunction”.
Further information at http://solvecfs.org/2017-ramsay-award-program-team-1.
There are 4 other awards listed but I particularly liked the look of this one.
Pam
Biomarkers for initiation (infection) and metabolic derangement in ME/CFS
A project summary as written by Drs. Blomberg, Bergquist, Gottfries, and Zachrisson:
Our working hypothesis of ME/CFS pathogenesis is that a person predisposed for ME through genetics and previous antigen exposure is infected with a microbe prone to elicit ME. These microbial antigens have epitopes which cross-react with self-epitopes. An (auto)immune response to this microbe which bypasses tolerance mechanisms is elicited. The cross-reactive immune response, e.g. autoantibodies, is directed against molecules involved in energy metabolism, hormonal regulation and, possibly, specific portions of the brain. In short, “infection elicited autoimmunometabolic dysfunction”.
Further information at http://solvecfs.org/2017-ramsay-award-program-team-1.
There are 4 other awards listed but I particularly liked the look of this one.
Pam