Invest in ME Conference 12: First Class in Every Way
OverTheHills wraps up our series of articles on this year's 12th Invest in ME International Conference (IIMEC12) in London with some reflections on her experience as a patient attending the conference for the first time.
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Solute Transporters and Health

Discussion in 'Genetic Testing and SNPs' started by ppodhajski, Aug 27, 2015.

  1. ppodhajski

    ppodhajski

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    Chapel Hill, NC
    I have been having an interesting time looking at the Solute Transporters (SLC) of all the 15 gene samples I have with people of varying levels of disease. I have noticed a trend, that the number of SLC gene SNPs that a persons has with a frequency of under 20% is correlated with health. Those with under 20 have very few health complaints. Those with 40 or more start showing signs of debilitating health. The sickest person I have genes for, a 26 year old female on disability for several degenerative diseases and mental health issues, has over 80 SLC SNPs under 20%!

    It is acknowledged they play a role in health
    http://www.ncbi.nlm.nih.gov/pubmed/23506860
    "The field of transport biology has steadily grown over the past decade and is now recognized as playing an important role in manifestation and treatment of disease."

    If you have you promethease report you can count these simply by searching for SLC, set the sort function to "Frequency", and increase the "Allow" number to 80. Then just scroll through and count.

    I made a video of how to do this here:


    If you want to check what your SLC gene SNPs might signal you can check what the the specific gene does here:
    http://www.bioparadigms.org/slc/intro.htm
    or
    http://www.genenames.org/genefamilies/SLC

    Here are my SNPs that are under 20%

    SLC28A2 Sodium/nucleoside
    SLC6A4 Serotonin
    SLC6A1 GABA
    SLC5A1 Sodium/Glucose
    SLC23A2 Sodium/Ascorbate
    SLC40A1 Iron
    SLC2A9 Urate Fructose
    SLC35F1 Drug Metabolite
    SLC45A3 Transmembrane Lipid?
    SLC4A1 Chloride/Bicarbonate
    SLC25A27 Proton Leak (Thermoregulation)
    SLC2A1 Glucose
    SLCO1B1 organic anions
    SLC23A2 Sodium/Ascorbate
    SLC6A3 Dopamine
    SLC2A2 Glucose
    SLC16A10 Aromatic Acids
    SLC1A2 Glutamate Aspratate
    SLC8A1 Calcium
    SLC6A2 Norepinepherine
    SLC6A4 Serotonin
    SLC45A2 May transport substances required for melanin biosynthesis
    SLC6A4 Serotonin
    SLC18A1 Biogenic Amines into Vascules
    SLC6A4 Serotonin
    SLC22A18 ?
    SLC36A3 Proton-coupled amino acid transporter
    SLC1A2 Glutamate Aspratate
    SLC45A2 May transport substances required for melanin biosynthesis
    SLC34A1 Phosphate
    SLC16A6 Monocarboxylate Transporter
    SLCO1B1 organic anions
    SLC28A1 Sodium Nucleotide
    SLC6A2 Norepinepherine
    SLC9A9 May act in electroneutral exchange of protons for Na+ across membranes.
    SLCO1B1 organic anions
    SLC16A6 Monocarboxylate Transporter
    SLC22A5 Carnitine
    SLC18A2 Vesicluar Amine Transporter
    SLC4A5 Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport,
    SLC2A2 Glucose
    SLC2A2 Glucose
    SLC25A43 Transmembrane Lipid?
     
    Last edited: Aug 27, 2015
    rosie26, merylg, South and 1 other person like this.
  2. ahmo

    ahmo Senior Member

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    I have 1 w/ 0%:D 26 under 20%, 5x 20.04%.
     
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  3. ppodhajski

    ppodhajski

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    Chapel Hill, NC
    Lucky! :)

    I am guessing the one at 0% is rs557881?
     
    Last edited: Aug 27, 2015
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  4. ahmo

    ahmo Senior Member

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    Northcoast NSW, Australia
    spot on:thumbsup:. GG.
     
  5. ppodhajski

    ppodhajski

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    That is a fascinating one to me. it seems it is on or off and I think it has something to do with awareness of some sor. Now sure how to express it. I do not have that one.
     
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  6. ahmo

    ahmo Senior Member

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    Northcoast NSW, Australia
    So how did you guess which one it is?
     
  7. ppodhajski

    ppodhajski

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    Chapel Hill, NC
    I really don't know. I have a weird brain. I just see it on and off and all the gene samples I have and it seems important.
     
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  8. Gondwanaland

    Gondwanaland Senior Member

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    What does 0% mean?

    I have 25 between 5.3 and 20%
     
  9. ppodhajski

    ppodhajski

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    Just that the genotype is very rare, close to zero percent.
     
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  10. Gondwanaland

    Gondwanaland Senior Member

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  11. skwag

    skwag Senior Member

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    37 under 20% here. A different 0% rs16923647 (T;T).

    Interestingly, six of those are red ( bad ), and the rest are not set.
     
    Last edited: Aug 27, 2015
  12. ppodhajski

    ppodhajski

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    Chapel Hill, NC
    Welcome to the club. :( Wondering about your health history?

    That is SLCO1A2, a bile acid transporter in the liver it seems. No idea what that means though.
     
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  13. mariovitali

    mariovitali Senior Member

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    Haha i have 43 under 20% Nice one! :thumbsup:

    I too have rs557881 at 0% and also rs9469300 at 0%. I would like to compare MANY more results from CFS sufferers with MANY more results of non-CFS sufferers as well though ;)


    Then i match "solute transporter" to my software :



    Now that is interesting, cholestasis and NAFLD were towards the top.

    car = constitutive androstane receptor
    pxr=pregnane x receptor
    rar = retinoic acid receptor
    udpglcnac = uridine diphosphate N-acetylglucosamine
     
    Last edited: Aug 28, 2015
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  14. Gondwanaland

    Gondwanaland Senior Member

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    DH has 65 from 0 to 20% :(

    The 0% is red +/- SLC6A12 rs557881
    [PMID 21367462] Association between SLC6A12 gene and negative symptoms of schizophrenia in Korean population.
    [PMID 20597903] Association of SLC6A12 variants with aspirin-intolerant asthma in a Korean population

    He is not Korean :D
     
  15. ahmo

    ahmo Senior Member

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    :eek::aghhh::hug:
     
  16. ppodhajski

    ppodhajski

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    I thought I knew what DH stood for now I don't .
     
    Last edited: Aug 28, 2015
  17. Gondwanaland

    Gondwanaland Senior Member

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    Dear Husband
     
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  18. ppodhajski

    ppodhajski

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    Just a note, that just studied these in the Korean population. It does not mean it does not have the same effect in others.
     
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  19. Strawberry

    Strawberry Senior Member

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    Dangit, you have my curiosity up again! I guess I should run my profile through Promethease.

    (welcome back)
     
  20. Gondwanaland

    Gondwanaland Senior Member

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    What can I do for DH's health based on these SNPs (and others)?
     

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