I keep trying methylfolate and experiencing unpleasant side effects around the 200mcg mark. I have been through years of oxidative stress and mitochondrial damage, and my antioxidant status was likely poor. I also have the SOD2 A16v homogyzous mutation. Naturopathic Dr. Ben Lynch says that if you have a SOD deficiency or mutation, there is a good chance you will experience side effects with methylfolate. He says: "Solution: The best way to support SOD is to make sure your red blood cell levels of manganese, zinc and copper are in the normal ranges. If they are and you have a SOD snp, then you may need to supplement SOD directly." -- It looks like there are two premiere SOD supplements options: "Gilisodin" is SOD-rich cannelouple extract bonded onto wheat protein to get it through the digestive system intact. "Extramel" a gluten-free, high-SOD French melon extract mircoencapsulated in palm oil. It sounds like Dr. Lynch is suggesting to get serum copper & zinc balanced and then try methylfolate again. Then try SOD if needed. Does anyone have experience improving SOD levels with zinc & copper balancing... or supplementing with SOD? Or with anything that addressed their SOD2 A16V mutation? Please share!