1. Patients launch $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
Can You Come for a Visit? My ME/CFS Says No
My daughter and son-in-law just had a baby last week. We are thrilled. But we won't be able to see the baby or hold her any time soon. We won't be able to take over little gifts or help out with housework or babysitting.
Discuss the article on the Forums.

SOD

Discussion in 'Genetic Testing and SNPs' started by LaurieL, Feb 1, 2013.

  1. LaurieL

    LaurieL Senior Member

    Messages:
    447
    Likes:
    239
    Midwest
    I have heard this before but can't remember.....;) I have done some re-reading but there seems to be a lot of conflicting information about the SOD's.

    I am curious as I have the +/+ mutation in SOD2 A16V, rs4880, amongst others. Some sources say this can be an up-regulation, others say it is a down-regulation. Anybody out there have any info or experience with this one?

    After doing the genetic genie detox profile, and also looking at the interferon and CCL mutations, I would say I have a bit of a problem with free radicals and detox.....and metalloproteins.

    Lauriel
  2. Pegasus

    Pegasus

    Messages:
    37
    Likes:
    4
    i have SOD wild type,i dont understand very well what it means,maybe someone can shed some light?

    The detoxigenomic test says :

    - - SOD2 A16V
    Health Implications: Superoxide dismutase (SOD) is the primary antioxidant enzyme within the mitochondria of
    cells (where most of our energy is made). SOD2 converts reactive oxygen species into less reactive hydrogen
    peroxide. The wild-type genotype (-/-) is associated with higher SOD2 activity and a greater sensitivity to antioxidant
    status compared to the other genotypes. The combination of higher SOD2 activity and low antioxidant intake and/or
    excessive oxidative stress (e.g., smoking) may result in an accumulation of hydrogen peroxide and increased risk of
    cancers of the breast or prostate. This genotype has also been associated with a higher risk of motor neuron
    disease. Risk of cancer may be reduced in individuals taking anti-oxidants.

    Minimizing Risk: Because the (-/-) genotype is particularly sensitive to antioxidant status, liberal consumption of
    dietary antioxidants in colorful vegetables and fruits is recommended. Broad-spectrum anti-oxidant supplements
    may also be helpful, including agents that help to raise glutathione levels (e.g., vitamin C, N-acetylcysteine, milk
    thistle) and support glutathione peroxidase (selenium). Consult your health care provider to find the supplement
    regimen that best fits your overall health anti-oxidant needs.

    thanks
  3. LaurieL

    LaurieL Senior Member

    Messages:
    447
    Likes:
    239
    Midwest
    I am +/+ for rs4880. I have not been able to compare other mutations in this gene set. So -/- is the upregulation and +/+ is the downregulation?

    I hope Pegasus, someone here will have some insight.
  4. triffid113

    triffid113 Day of the Square Peg

    Messages:
    702
    Likes:
    223
    Michigan
    Where did you get that gene mapped? I would like to find other gene panels that are worth getting. I got the holisticheal (Yasko) panel and have 18 genetic defects, none of which govern my allergies nor drug sensitivities, so I'd like to map more when cost-effective panels come available. Thanks
  5. Pegasus

    Pegasus

    Messages:
    37
    Likes:
    4
    this test is called Detoxigenomics,and tests a separate system that isnĀ“t in the yasko test.
    It tests the genetic profile of the body to detox environmental toxins,etc as well as your on "waste" byproducts,so to say.

    you can find more in the lab site,Genova Diagnostics,www.gdx.net
  6. dotdot

    dotdot

    Messages:
    15
    Likes:
    0
    London, UK
    I had my genetic profile done by 23andme, which costs $99, then ran my 23andme raw data through GeneticGenie
    http://geneticgenie.org

See more popular forum discussions.

Share This Page