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SOD mimetic inhibits immune response in cerebral malaria

Discussion in 'Other Health News and Research' started by cigana, Jun 24, 2014.

  1. cigana

    cigana Senior Member

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    It is interesting how this suggests that immune activation can be inhibited by an enzyme that prevents oxidative stress:
    http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087140

    A user on this forum @Bluebrid has found this mimetic to be very helpful.
    AbbyDear likes this.
  2. Bluebrid

    Bluebrid

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    Tempol is often used in research to test whether or not a condition is related to free radical stress. Interesting that Tempol attenuated the hyper-coagulation and inflammatory response to cerebral malaria. It is most likely due to the improved cell signaling.

    One of the infections I contracted prior to taking Tempol was severe babesiosis. Babesia is considered a “cousin” of malaria. Most people are able to clear babesia on their own. However with my genes, free radical stress and the toxins I had encountered, babesia was shutting down my immune system. The clotting issues were so bad, they thought I was having mini strokes -- and then I was hospitalized with a DVT and PEs. 2/3 of my lungs were full of clots by the time I got to the hospital.

    In retrospect, the integrative MD said that the SOD SNP is most likely the reason I was not able to handle the babesiosis without intervention. As I had not yet found Tempol -- and it took over 6 months of high dose malaria meds to clear the infection. The meds, infections and clotting issues definitely took a toll on my body.
    AbbyDear, merylg and cigana like this.

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