Hello I'm new here. I have been really unwell for about 8 months and on/off for a year in total. Symptoms are extensive - fatigue, brain fog, blurred vision,numbness tingling in face, arms and legs. Joint pains, stiffness, fevers, twitching, restless legs, insomnia, vertigo, lethargy, metallic taste in mouth, gluten intolerance, pressure in head behind eyes, swollen optic discs, raised intracranial pressure, thyroid and pituitary problems. That's some of it. I've had lots of tests, Comprehensive stool analysis, stress profile, lyme testing, Ct head, MRI Head, Hair analysis loads of bloods done at my GP office. Main summary so far Treated for Lyme based on symptoms and Igenex Test IGM 31 IND 39 IND 41+ IgG 23-25 IND 39 IND 41+ No parasites or H. Pylori Normal sleep study Adrenal fatigue B12 initially low at 207 ng/l but daily injection of Methylcobalamin put this up above 1500 Ferritin between 14-19 Mcg/l no response to treatment Vitamin D 13.4 then 25.4 few weeks later Most recently had 23andme test done which shows +/+ VDR Bsm & MAO A R297R +/- COMT V158M, COMTH62H, MTHFR C677T, MTHFR A1298C, MTRR K350A, and CBS C699T. So I think this means I am compound heterozygous for MTHFR and the CBS C699T further complicates this. I have 3 amalgam fillings and have had many vaccinations due to my work. Just prior to becoming ill I did the Dukan diet (high protein) which it seems may have aggravated the CBS problem. It’s all so confusing and Doctors in the UK have no idea about any of this, in fact I have seen Dr’s in Endocrinology (thyroid) waiting for pituitary as well, neurology, ophthalmology, infectious diseases, waiting for gastroenterology for weight loss, as well as my own GP on numerous occasions and none of them look at the whole picture and are just interested in their own area. I am on my own in this, I have a huge collection of vitamins and supplement bought over the last 8 months some help a little others make things worse. I started methylfolate a few months ago as I guessed I had the MTHFR problem based on symptoms but I had an awful time when I took it, felt like lots of electrical impulses in my head and awake all night. Currently I am on Probiotics, selenium, pantothenic acid, and yesterday I started manganese and have bought L Ornithine to start in a few days. I am thinking I will go out today and buy molybdenum as well. I have read some of Dr Yasko’s book but I am unable to access tests, I fought with the neurologist yesterday to measure my mercury and aluminium levels but she doesn’t think the lab will carry out the tests. I have sent a hair sample off a few days ago for mineral testing privately but haven’t heard about any results yet. Any help would be much appreciated. Thank you for reading.