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Hi everyone!
I’m seeking some advice regarding my daughter who does not have CFS but suffers from autism and has been gradually regressing in terms of behavior, tantrums and anxiety. She is also non verbal. The home situation is very stressful due to these issues, and it’s hard imagine she’s not even 2 years old yet!! She and her healthy twin sister will be 2 in a few weeks. Anyway we’ve been pursuing the biomedical route with no success.
Attached is her SNP profile.
To everyone’s surprise her bloodwork was essentially perfect. Homocysteine being 5 . She has normal to high levels of b12 in her blood so our doctor did not want to pursue supplementation although I’m now reading that high levels in the blood don’t necessarily indicate high levels in the tissue or that it’s being absorbed, that it’s essentially just floating around unused because she doesn’t have the proper genes to convert. Due to her homozygous mutation, it was strange to see her levels look so good - so I’m not completely sold on her not needing b12.
The complicating factors are her heterozygous COMT and VDR taq which indicates a methyl intolerance.
I have read in this case it is better supplement Hydroxocobalamin and Adenosylcobalamin as opposed to Methylcobalamin. I’m also reading about the use of lithium orotate and it’s importance before introducing more methyl donors. This is now kind of over our doctors head, and my own because her situation is very complex.
He recommended a cocktail of:
250mg tmg liquid
1000mcg methylfolate
Omega 3 Fish oil (higher dha ratio)
Probiotics
Biocidin
She is currently taking just the TMG along with her multivitamin (pure encapsulations junior, 1 cap). I’m being very conservative with adding each supplement one at a time to watch out for any negative side effects. She’s been on the TMG for 2 weeks now with no positive effect... maybe even worsening of behavior but it’s hard to say. Now since discovering the potential for methyl intolerance I’m considering adding a very low dose Lithium Orotate (2.5 mg) to see if this can help balance her out.
Does anyone have any advice on where to go from here? Any guidance would be very much appreciated!!!
I’m seeking some advice regarding my daughter who does not have CFS but suffers from autism and has been gradually regressing in terms of behavior, tantrums and anxiety. She is also non verbal. The home situation is very stressful due to these issues, and it’s hard imagine she’s not even 2 years old yet!! She and her healthy twin sister will be 2 in a few weeks. Anyway we’ve been pursuing the biomedical route with no success.
Attached is her SNP profile.
To everyone’s surprise her bloodwork was essentially perfect. Homocysteine being 5 . She has normal to high levels of b12 in her blood so our doctor did not want to pursue supplementation although I’m now reading that high levels in the blood don’t necessarily indicate high levels in the tissue or that it’s being absorbed, that it’s essentially just floating around unused because she doesn’t have the proper genes to convert. Due to her homozygous mutation, it was strange to see her levels look so good - so I’m not completely sold on her not needing b12.
The complicating factors are her heterozygous COMT and VDR taq which indicates a methyl intolerance.
I have read in this case it is better supplement Hydroxocobalamin and Adenosylcobalamin as opposed to Methylcobalamin. I’m also reading about the use of lithium orotate and it’s importance before introducing more methyl donors. This is now kind of over our doctors head, and my own because her situation is very complex.
He recommended a cocktail of:
250mg tmg liquid
1000mcg methylfolate
Omega 3 Fish oil (higher dha ratio)
Probiotics
Biocidin
She is currently taking just the TMG along with her multivitamin (pure encapsulations junior, 1 cap). I’m being very conservative with adding each supplement one at a time to watch out for any negative side effects. She’s been on the TMG for 2 weeks now with no positive effect... maybe even worsening of behavior but it’s hard to say. Now since discovering the potential for methyl intolerance I’m considering adding a very low dose Lithium Orotate (2.5 mg) to see if this can help balance her out.
Does anyone have any advice on where to go from here? Any guidance would be very much appreciated!!!