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SNP Results - Any help greatly appreciated!

Discussion in 'Genetic Testing and SNPs' started by LucyS, Sep 6, 2013.

  1. LucyS

    LucyS

    Messages:
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    Likes:
    10
    Australia
    Hello wise and learned folks,
    I have my 23 andMe results in and as I am Down Under there are not many here who know much about this! Any information or advice from these results would be sooooo greatly appreciated! I have a very long history of very severe CFS - Thanks

    DETOX
    CYP 1A2 C164A - CC +\+
    CYP 1B1 L432V - CG +\-
    CYP 1B1 R48G - CG +\-

    SOD2 - AC +\-
    SOD2 - CT +\-
    SOD2 A16V AG +\-

    METHYLATION
    HOMOZYGOUS
    VDR Taq
    CBS C699T
    COMT rs6269

    HETEROZYGOUS
    MAO A R297R
    ACAT1-02
    MTHFR 677
    MTRR A66G
    MTRR A664A
    GAD1 10 out of 12 +\-

    Thank you all so much -
  2. Valentijn

    Valentijn Activity Level: 3

    Messages:
    5,645
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    7,260
    Amersfoort, Netherlands
    I've crossed out the ones where there's no research showing that they cause any problems.

    Heterozygous MTHFR C677T indicates that your methylfolate production might be at 65% of normal, hence methylfolate supplementation is a good idea.

    MTRR A66G works less efficiently at recycling MTR. B12 may help.

    I'm not sure which version of COMT rs6269 is considered +/+ in your results. The A version is slower, and that and the MOAO would indicate less tolerance of methyl groups. Hence hydroxoB12 might be better tolerated than methylB12, especially if you try higher doses.

    SUMMARY:
    Methylfolate supplementation is probably needed, and hydroxoB12 may help as well.

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