I'm just finishing my 10th week on the SMP with no discernible improvement on energy, sleep, number of symptoms, etc. (I've kept very detailed records and the lack of change is clear). There's a possibility I've caught fewer winter bugs than normal and been less affected by what I have got but without a control condition, hard to attribute this to the SMP. I tried Fred's protocol before the SMP and had immediate and clearcut improvements on energy and concentration. However, the benefits went away and I started to get sore muscles and profound exhaustion and no matter how much potassium and magnesium I took, things kept getting worse. Eventually I had to stop because I was losing the ability to get out of the house and to look after myself. It was clear that Fred's protocol was doing something good in the early stages and I'd hoped that a switch to the gentler (lower dose) SMP might help. However, as I near the critical 3-month mark, I can see no sign of the same benefits that other people have had by that time (in the study with Dr Nathan, for example). I'm in the UK and don't know how to get a blood test to send to Health Diagnostics (I'm reluctant to ask my NHS GP for a test he might think weird; I also don't know the practicalities of getting it done, given that the NHS almost certainly won't pay and I'd welcome advice on this from UK people). I can't even find a website for Health Diagnostics to get details of what's involved. Sianrecovery has found that Holistic Heal do a test from a pinprick sample that doesn't involve getting a doctor's order (much preferable!) but she says it's genetic rather than functional so I'd be grateful for advice on how helpful it would be in guiding what supplements to take. I assume it's this one. I'd be grateful for advice on the testing, since it seems nuts to try endless variations on the protocols in the hope of hitting a combo that helps me - I still have no clue how to tell a start-up reaction from a sign it's all going wrong and I've already been on one version or another of the protocols for six months. If I can't get testing, though, I wonder if it makes sense to swap the 2mg of hB12 for 1mg aB12 + 1mg mB12 and keep the other SMP stuff the same?