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Small molecule that inhibits androgen receptor could treat prostate cancer

Discussion in 'Other Health News and Research' started by Rosemary, Jun 18, 2010.

  1. Rosemary

    Rosemary Senior Member

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    Can anyone please access this article ?

    Androgen receptor

    In vitro and mouse studies identified a small molecule from Geodia lindgreni that inhibits androgen receptor and could treat prostate cancer. Further details on the research, next steps and licensing status are discussed in the article.

    http://www.nature.com/scibx/journal/v3/n24/full/scibx.2010.726.html

    BTW Geodia lindgreni is a marine sponge
  2. FernRhizome

    FernRhizome Senior Member

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    Rosemary:
    Maybe you should send this to WPI???? Or post it to their site? ~Fern
  3. Rosemary

    Rosemary Senior Member

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    A good idea ! ... thanks Fern

    Here is some further information

    In vitro and mouse studies identified a small molecule from Geodia lindgreni that inhibits androgen receptor and could treat prostate cancer. Screening and in vitro testing of marine sponge extracts identified a compound that inhibited the N-terminal domain of androgen receptor. In three human prostate cancer cell lines, the compound reduced androgen receptor-dependent proliferation compared with no treatment. In mice with androgen-sensitive and castration-resistant prostate cancer (CRPC) xenografts, the compound reduced tumor growth compared with no treatment. Ongoing work includes optimization of the lead compound.
    MDV3100, a triple-acting oral anti-androgen receptor from Medivation Inc. and Astellas Pharma Inc., is in Phase III testing to treat CRPC.
    Tokai Pharmaceuticals Inc.'s TOK-001, a selective androgen receptor modulator (SARM) and inhibitor of cytochrome P450 17 a-hydroxylase/C17, 20 lyase (CYP17), is in Phase I/II testing to treat CRPC.
    Aragon Pharmaceuticals Inc.'s ARN-509, a small molecule that binds androgen receptor, is in preclinical development to treat CRPC.

    Patented by The University of British Columbia and the BC Cancer Agency; licensing status undisclosed

    Andersen, R.J. et al. Cancer Cell; published online June 13, 2010;
    doi:10.1016/j.ccr.2010.04.027
    Contact: Marianne D. Sadar,
    BC Cancer Agency, Vancouver,
    British Columbia, Canada
    e-mail:
    msadar@bcgsc.ca

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