I cant seem to find if these herpes viruses replicate quickly or slowly. Can someone answer this for me. WHy I ask is that av's have a short half life like 2-3hrs, so is it more beneficial to split your dosages in 2-3 doses a day or 1 big dose a day which would greatly increase blood levels and tissue penetration. If these viruses are slowly replicating then one big dose a day would probably be better. I have recently changed my dosage of famvir from 250mg twice a day to 500mg once a day with probenecid which probenecid also increases blood levels and half life of av's and abx. Im not sure how much it increases the half life of av's but if u can get a few more hours out of the drug then thats great. cheers!!!