glad that stuff is working for you Caroljean. i develop a tolerance to meds pretty quickly too. i'm afraid my sleep issues are past the Kava Gaba Worty Rooty stuff, i tried all of that for over a decade trying not to give in to meds. but i gave in, & now i sleep better - tho i have other isseus, all the dang meds come with side effects. it's obviously far better for you to not have to use the hard core stuff, so i hope it keeps working for you. i have a friend who also has IC who swears by all the 5HTP NAC SamE stuff.