http://web.mit.edu/zakf/www/drugchart/drugchart11.html The above link shows all the inhibatory and excitory affects of neurotransmitters as well as blocking these effects can cause the opposite reaction. A normal person wakes up in the morning and most of those excitary neuros kick in, in a balanced way and over the course of the day they dwindle down and at night the inhibatory neuros kick in and we go to sleep. Also mixed in to confuse the whole matter is of cause our hormones especially cortisol, dhea and sex hormones. We better not forget cytokines from infections and inflammation. In cfs/me these are totally out of whack and is a major part of the reason its seen also as a neurological illness as well as immune illness. Trying to control them is almost impossible but we try with sleep meds , stimulants any other drug that effects the brain etc Especially with us i think, when we change a certain function with a drug the body compensates by trying to correct this or over compensates when the drug affects are gone, which i think happens alot with benzo sleep meds and also rebound insomnia when one doesnt take a sleep med. Also some meds affect several neuros eg alot of tricyclic meds also have antihistamine effects as well as effect serotonin, noradrenaline and dopamine. Some of these neuros are also broken down further eg serotonin has several different serotonin receptors, bloking the effects of 5htp2a and 5htp2c has sedative effects and is what drugs like trazadone and mirtazapine do where some ssri's dont block these receptors so they help impove mood and energy but then continuing working and worsening sleep for some. This is why many of us are sensitive to antidepressants. How all these neuros work is sort of my plan on how i use my sleep stack med protocol, generally a benzo as its the main inhibitory neuro, then i will add something that effects the histamine receptors and then maybe something that blocks 5htp2a/c. There are other neuro's etc like melatonin that i could use but its apart of rotating things to help prevent tolerance etc. Of late i have also been experimenting with increasing acetylcholine to help improve cognition and general energy levels which it has. Also noradrenaline with acetly tyrosine. Every so often even when using these meds i will have a night out of the blue where i just cant sleep, which is why i posted an insomnia rant. I think what happens is that the body wants to get back to its dysfunctional homeostasis or its normal crappy self. No matter what u do it will do the opposite. Even if we didnt try to control these bloody neuro's, this dam ME still dose a good job of mixing everything up anyway, so dammed if we do and dammed if we dont. At the end of the day i have probably confused everyone like i have myself, lol. Shows how complicated this stuff is and i dont think anyone really has a grasp of it including neurologists and psychiatrist. We can control these functions with meds and supps to a certain degree and this can help us to function in a normal world, but its no cure, its treating symptoms on a deeper level. In ME/cfs our body doesnt like to be normal so if we try to correct things its always pushing against us. This is one reason why i think with any med or supplement that we need to take breaks, chop and change to keep our dysfunctional brain off guard. Also retry things u might have used in the past that didnt help, our body might be in a different dysfunctional state that may respond to something that we once didnt respond too. We have to be our own doctors because we are the only ones who know whats going on in this brain/body of ours which needs constant changing. I think we will forever be experimenting with different things and have a cupboard full of half used meds and supps that we will dip into for short periods, tinkering all the time. I wish i didnt have to but it does give me more functional days then i would if i didnt. We are a complicated mess, might be why alot of docs dont like treating us. It would be much easier if we had an off/on switch, probably how the saying uppers and downers came about as they tried to control their bodily functions but its not that simple Enough of my rant, cheers!!!