Review: 'Through the Shadowlands’ describes Julie Rehmeyer's ME/CFS Odyssey
I should note at the outset that this review is based on an audio version of the galleys and the epilogue from the finished work. Julie Rehmeyer sent me the final version as a PDF, but for some reason my text to voice software (Kurzweil) had issues with it. I understand that it is...
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SLC35F3 rs12049593 Thiamine transport

Discussion in 'Genetic Testing and SNPs' started by Nine lives, Mar 5, 2018.

  1. Nine lives

    Nine lives

    So, in past year I noticed that I respond positively to benfothiamine, sulbutiamine. A subset of people here seem to get improvements from these thiamine based supplements. When I increase carbs to 100 grams a day I need more pills (4 a day). Back to low carb, I am back to 1 tablet a day.

    I am T/T for rs12049593 (0.0088 op European population).

    This snp has been discussed in regard neanderthal dna. Specifically, in this paper:
    The phenotypic legacy of admixture between modern humans and ...

    This snp affects thiamine transport in the brain and gut and at its worst is implicated in protein calorie malnutrition.

    For those helped by thiamine and have 23andme, might be worth checking this out.
    nanonug and sb4 like this.
  2. aquariusgirl

    aquariusgirl Senior Member

    Susan Costen Owens, an oxalates, sulphur researcher, thinks thiamine tranposters are a factor for her family & their health issues
    she is knowledgeable on this subject
    she posts on Trying Low Oxalates on FAcebook group
    she mentioned SLC44A5 to me
  3. Nine lives

    Nine lives

    Thanks! Already a member there but I have not checked in recently since my oxalates are low. But, yes, she has some good stuff on thiamine so I appreciate the reminder!
  4. sb4

    sb4 Senior Member

    United Kingdom
    Interesting. I am C/C for that one. I have noticed that the heavy heart pounding that I get from increased carbs is diminished somewhat with allithiamine however this then creates other problems such as insomnia.
    nanonug likes this.
  5. nanonug

    nanonug Senior Member

    Virginia, USA
    Thanks for the pointer on allithiamine. I'm also C/C and also get the heart pounding problem. I'm going to give allithiamine a try and see what happens.
    sb4 likes this.

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