Severe ME Day of Understanding and Remembrance: Aug. 8, 2017
Determined to paper the Internet with articles about ME, Jody Smith brings some additional focus to Severe Myalgic Encephalomyelitis Day of Understanding and Remembrance on Aug. 8, 2017 ...
Discuss the article on the Forums.

Skip Pridgen's Phase II Clinical Trial Results Published

Discussion in 'Other Health News and Research' started by Never Give Up, Mar 26, 2017.

  1. Never Give Up

    Never Give Up Collecting improvements, until there's a cure.

    Messages:
    938
    Likes:
    3,879
    Cort has written up a summary here:

    http://simmaronresearch.com/2017/03/valley-death-fibromyalgia-pridgen/

    The original 26 page paper is here:

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328426/

    Cutting to the chase:

    1. statistically significant improvements in pain, fatigue, IBS, and depression were present,

    2. Dr. Pridgen expects more robust results when he is allowed to use higher doses of the drugs in the phase III trials which they are now gearing up for, and

    3. "analysis of FM patients gut tissue is complete and that the data that emerged “far surpassed” their expectations".
     
    dangermouse, Skippa, merylg and 9 others like this.
  2. Jon_Tradicionali

    Jon_Tradicionali Alone & Wandering

    Messages:
    290
    Likes:
    321
    Zogor-Ndreaj, Shkodër, Albania
    He had originality said to have found active HSV-1 viral proteins in over 90% of FM patients' gut biopsy samples. That finding alone is impressive. The treatment results, not so much.
     
    Sancar and merylg like this.
  3. Never Give Up

    Never Give Up Collecting improvements, until there's a cure.

    Messages:
    938
    Likes:
    3,879
    Do you remember what percentage of controls he originally said had HSV-1?
     
    barbc56 likes this.
  4. arewenearlythereyet

    arewenearlythereyet Biscuit Antagonist

    Messages:
    1,284
    Likes:
    5,552
    Uk
    Great that he's got funding for clinical trials later this year. Looks like the fatigue score will need some scrutiny though to check it is meaningful.
     
  5. Jon_Tradicionali

    Jon_Tradicionali Alone & Wandering

    Messages:
    290
    Likes:
    321
    Zogor-Ndreaj, Shkodër, Albania
    I haven't talked to him in over a year but the patients were at 95% and controls at 1% or 3% (cannot remember which).

    I remember asking him why, if he believes active HSV1 to be the true cause of FM, active proteins were not found in 100% of patients,
    He told me it was very likely that the biopsy sample was not of tissue with residing HSV1,
    He was sure subsequent biopsies would prove 100% active HSV1 in all patients.
     
    Hutan and Never Give Up like this.
  6. Never Give Up

    Never Give Up Collecting improvements, until there's a cure.

    Messages:
    938
    Likes:
    3,879
    That's very impressive.
     
    Jan likes this.
  7. knackers323

    knackers323 Senior Member

    Messages:
    1,248
    Likes:
    346
    Since these are fm patients what are the suggested implications for cfs?
     
  8. ryan31337

    ryan31337 Senior Member

    Messages:
    396
    Likes:
    883
    South East, England
    Interesting! I doubt I'd qualify for fibro diagnosis as tender points and pain are not key symptoms for me. However, one of my oldest and most consistent symptoms has been throbbing calf pain, usually delayed after exertion or poor sleep.

    I had the exact same throbbing pain, but very much amplified and present in both legs, for a few days and appeared to be prodromal to an episode of HSV-1 reactivation (confirmed later by swab).
     
  9. TreePerson

    TreePerson Senior Member

    Messages:
    168
    Likes:
    792
    U.K.
    I find this interesting. I've had ME for 24 years and was recently given high dose acyclovir for shingles. I felt better while I was on it in the sense that I had noticeably more energy could function at a higher level. I had a lot of viral symptoms but then I had shingles. It was my first experience of an anti herpes drug.
     
  10. Jon_Tradicionali

    Jon_Tradicionali Alone & Wandering

    Messages:
    290
    Likes:
    321
    Zogor-Ndreaj, Shkodër, Albania
    Pridgen believes CFS is also a part of the spectrum of syndromes caused by HSV1.
    FM is at the severe end of this spectrum.
     
  11. Never Give Up

    Never Give Up Collecting improvements, until there's a cure.

    Messages:
    938
    Likes:
    3,879
    Hahahahahaha! If only!
     
    Sancar and justy like this.
  12. barbc56

    barbc56 Senior Member

    Messages:
    3,526
    Likes:
    4,123
    Is this seen in any other health conditions?
     
  13. ljimbo423

    ljimbo423 Senior Member

    Messages:
    393
    Likes:
    582
    United States, New Hampshire
    Dr. Pridgen seems to think there's an underlying immune system problem that allows the HSV1 to flourish, according to Cort Johnson.

    So the real cause (from Dr.Prigen's view) is not the virus itself, but the immune system problems/dysfunction that allow it to reactivate. I am treating my immune system dysfunction, as I believe it is one of the core issues in causing cfs.
     
    Last edited: Mar 30, 2017
  14. Navid

    Navid Senior Member

    Messages:
    467
    Likes:
    304
    Does anyone know what the protocol entails?

    Thanks
     

See more popular forum discussions.

Share This Page