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Six strains of XMRV so far!

Discussion in 'XMRV Research and Replication Studies' started by FernRhizome, Apr 10, 2010.

  1. FernRhizome

    FernRhizome Senior Member

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    This abstract mentions there are now SIX strains of XMRV identified......


    'Xenotropic Murine Leukemia Virus-Related Virus in Chronic Fatigue
    Syndrome and Prostate Cancer'
    James N. Baraniuk
    Curr Allergy Asthma Rep
    DOI 10.1007/s11882-010-0106-2


    http://www.springerlink.com/content/416lq773u356024x/?p=564983864c6a4af683c2f38786162c61&pi=0

    Abstract

    Xenotropic murine leukemia virus-related virus (XMRV) is a γ
    retrovirus that has been associated with chronic fatigue syndrome
    (CFS) and prostate cancer. The search for viral causes of these
    syndromes was reignited by the finding that RNase L activity was low
    in hereditary prostate cancer and some CFS patients. The six strains
    of XMRV that have been sequenced have greater than 99% identity,
    indicating a new human infection rather than laboratory contamination.
    DNA, RNA, and proteins from XMRV have been detected in 50% to 67% of
    CFS patients and in about 3.7% of healthy controls. XMRV infections
    could be transmitted to permissive cell lines from CFS plasma,
    suggesting the potential for communicable and blood-borne spread of
    the virus and potentially CFS. This troubling concept is currently
    under intense evaluation. The most important steps now are to
    independently confirm the initial findings; develop reliable assays of
    biomarkers; and to move on to investigations of XMRV pathophysiology
    and treatment in CFS, prostate cancer, and potentially other
    virus-related syndromes, if they exist.
  2. Adam

    Adam *****

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    Sheffield UK
    Do we know who James N. Baraniuk is? Or what his interest is?

    Very interesting find. Many thanks.
  3. V99

    V99 *****

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    Excellent find
  4. hvs

    hvs Senior Member

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    Dr. Baraniuk was the final signatory to the following paper, in which researchers appeared to make a good faith effort to identify biomarkers among CFS and FM patients:
    "Urinary electrophoretic profiles from chronic fatigue syndrome and chronic fatigue syndrome/fibromyalgia patients: a pilot study for achieving their normalization," Journal Of Chromatography, B, (Jan. 2005): 43-51.
    From the abstract: "Aim of our study was to determine if there were distinct, disease-related patterns of urinary analytes in chronic fatigue syndrome (CFS) and chronic fatigue syndrome/fibromyalgia (CFS/FM) compared to normal controls (NC). ...CFS/FM and CFS had significant differences in peaks compared to NC that may be of significance as biomarkers of illnesses."
  5. starryeyes

    starryeyes Senior Member

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    Bay Area, California
    Six strains. That's interesting. Thanks for posting this Fern. They say that now there's no chance of XMRV being a laboratory contamination.
  6. shrewsbury

    shrewsbury member

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    I know Fern; I thought that info re 6 strains of xmrv, 99% identical, was a gem hidden in there!

    I think James Baraniuk is the lead on the spinal tap clinical trial (proteins in the cerebral fluid + brain) that Cort took part in and wrote about. Or more formally, Proteomics of Cerebrospinal Fluid in Chronic Fatigue Syndrome

    I'm looking forward to the full article to see if he ties xmrv to his work to date.
  7. lansbergen

    lansbergen Senior Member

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    A chronic fatigue syndrome related proteome in human cerebrospinal fluid

    James N Baraniuk1 email, Begona Casado1,2 email, Hilda Maibach1 email, Daniel J Clauw3 email, Lewis K Pannell4,5 email and Sonja Hess S5 email

    1 Georgetown University Proteomics Laboratory, Division of Rheumatology, Immunology & Allergy, Room B-105, Lower Level Kober-Cogan Building, Georgetown University, 3800 Reservoir Road, N.W., Washington DC 20007-2197, USA

    2 Dipartimento di Biochimica A. Castellani, Universita di Pavia, Italy

    3 Center for the Advancement of Clinical Research, The University of Michigan, Ann Arbor, MI, USA

    4 Proteomics and Mass Spectrometry Facility, Cancer Research Institute, University of South Alabama, Mobile, AL, USA

    5 Proteomics and Mass Spectrometry Facility, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0508, USA

    author email corresponding author email

    BMC Neurology 2005, 5:22doi:10.1186/1471-2377-5-22

    The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1471-2377/5/22
    Received: 11 April 2005
    Accepted: 1 December 2005
    Published: 1 December 2005
  8. hvs

    hvs Senior Member

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    This is a very significant thing to have stated in a peer-reviewed article.
  9. Abraxas

    Abraxas Senior Member

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  10. FernRhizome

    FernRhizome Senior Member

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    Abraxas:
    I tried that link and it only brought up the first page.....can we possibly get the entire article? Thanks!!! ~Fern
  11. Abraxas

    Abraxas Senior Member

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    Hi Fern, yes the preview only shows the first page and I don't have access to the full study. Does anyone else? :Sign Help:
  12. JT1024

    JT1024 Senior Member

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    Massachusetts
    I'll be at work this afternoon and I may have access (I work in a hospital and have access to many online journals and resources). Hopefully, I'll be able to access it.
  13. Dr. Yes

    Dr. Yes Shame on You

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  14. dancer

    dancer Senior Member

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    Midwest, USA
    Could someone please share a few highlights (for those of use newbies who can't access the library)?

    I loved this from the first page:

    "The new finding of XMRV in CFS must make us pause and
    take a fresh look at these frustrated and disillusioned victims of
    medical neglect."
  15. _Kim_

    _Kim_ Guest

    I posted the full text in the Library.
    Baruniak 2010 - Xenotropic Murine Leukemia Virus-Related Virus in CFS and Prostate...

    Another great line:
    This is who funded the study:
    Acknowledgments This work was supported by US Public Health Service Award RO1 ES015382 from the National Institute of Environmental and Health Sciences; Department of Defense Congressionally Directed Medical Research Program W81XWH-07-1-0618; and M01-RR13297 from the General Clinical Research Center Program, National Center for Research Resources, National Institutes of Health.
  16. joyscobby

    joyscobby Senior Member

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    50%?

    Where does the 50% come from in red bellow. The 67% is obviously the Science paper but can any one else clear this up?


    'Xenotropic Murine Leukemia Virus-Related Virus in Chronic Fatigue
    Syndrome and Prostate Cancer'
    James N. Baraniuk
    Curr Allergy Asthma Rep
    DOI 10.1007/s11882-010-0106-2


    http://www.springerlink.com/content/416lq773u356024x/?p=564983864c6a4af683c2f38786162c61&pi=0

    Abstract

    Xenotropic murine leukemia virus-related virus (XMRV) is a γ
    retrovirus that has been associated with chronic fatigue syndrome
    (CFS) and prostate cancer. The search for viral causes of these
    syndromes was reignited by the finding that RNase L activity was low
    in hereditary prostate cancer and some CFS patients. The six strains
    of XMRV that have been sequenced have greater than 99% identity,
    indicating a new human infection rather than laboratory contamination.
    DNA, RNA, and proteins from XMRV have been detected in 50% to 67% of
    CFS patients and in about 3.7% of healthy controls. XMRV infections

    could be transmitted to permissive cell lines from CFS plasma,
    suggesting the potential for communicable and blood-borne spread of
    the virus and potentially CFS. This troubling concept is currently
    under intense evaluation. The most important steps now are to
    independently confirm the initial findings; develop reliable assays of
    biomarkers; and to move on to investigations of XMRV pathophysiology
    and treatment in CFS, prostate cancer, and potentially other
    virus-related syndromes, if they exist.[/QUOTE]
  17. garcia

    garcia Aristocrat Extraordinaire

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    London, UK
    Thanks Kim! Did I mention you are a star? :Sign Good Job:

    With respect to that excellent quote you pulled-out: Here, here!
  18. gracenote

    gracenote All shall be well . . .

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    Santa Rosa, CA
    Here is the conclusion of the paper.

  19. dancer

    dancer Senior Member

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    Midwest, USA
    Thanks, gracenote!
    I'm riveted to every tidbit of info on XMRV... this is better than reading a good mystery novel. :)
  20. _Kim_

    _Kim_ Guest

    Aw garcia...I'm no star, just someone who has University Library privileges. Thanks though.

    This is fascinating. I've not seen this before. At the end of the reference section, Baruniak lists the van Kuppeveld study (#24) AND adds his own comment. Who knew you could comment on the references you cite?

    And he does the same for this article (#25):

    I also have posted this one in the Library: Voisset 2008 - Human RNA “Rumor” Viruses: the Search for Novel Human Retroviruses...

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