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Simplified Methylation Protocol Revised as of Today

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by richvank, Mar 30, 2011.

  1. richvank

    richvank Senior Member

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    Hi, alice.

    In our clinical study of the simplified protocol, we did not supplement glutathione, and it came up automatically. This was the breakthrough in autism research in 2004, and we found that the same applies in ME/CFS.

    For people who suffer excitotoxicity symptoms on the simplified protocol (anxiety, insomnia, nervousness) I have suggested adding glutathione support, either liposomal or acetyl glutathione. I've received only a little feedback on this, but it does seem to help some people.

    When I speak of a high dosage of B12, I mean in comparison to the RDA level for B12, which is only a few micrograms per day. The simplified protocol suggests 2 milligrams per day sublingual, and I think that would apply approximately to either hydroxocobalamin or methylcobalamin. People differ in what they need, so it may require some experimentation to find a dosage that is helpful and tolerable.

    I presume that you mean milligrams when you write MG. A capital M means mega.

    When a large dosage of B12 is swallowed, about 1% of it is absorbed by diffusion in the gut. So if you are referring to 25 milligrams of B12, that would be 25,000 micrograms, and 1% of that would be 250 micrograms. This is approaching an effective dosage for ME/CFS, but I think it would still be necessary to take some sublingually in addition.

    If you mean 40 milligrams of folate taken orally, yes, that's a lot. Most PWMEs need only about an RDA level of one of the active forms of folate, which is less than 1 milligram per day.

    Best regards,

    Rich
     
  2. Lynn_M

    Lynn_M Senior Member

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    Rich,
    I see that the HDRI methylation pathways panel does not measure B12 . Will the test results indicate if there functional sufficiency of B12? Will they indicate if I need to take more B12?
     
  3. richvank

    richvank Senior Member

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    Hi, Lynn.

    It's true that the HDRI panel does not measure B12. The European Lab of Nutrients version includes a measurement of methylcobalamin. On the HDRI panel, if there is a partial methylation cycle block and glutathione depletion, a functional B12 deficiency can be inferred on the basis of the 2011 Korean paper that I have been citing lately. When glutathione goes down, the affinity of CblC for cobalamin drops drastically, and that causes the functional B12 deficiency, which in turn causes the partial block in the methylation cycle, according to my hypothesis. If there is a partial methylation cycle block, both B12 and folate are needed to lift it.

    Best regards,

    Rich
     
  4. Debi

    Debi

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  5. Debi

    Debi

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    Hello,
    I am new to this forum, so forgive me if I am in the wrong place - perhaps you can direct me. I have not seen anyone talk about their test results for methylation cycle testing by Yasko. I took the test and know where my mutations are, I just need help interpreting it and working out a plan of action with someone skilled in this. Due to the number of mutations, there are things you would do for CBS issues are not the same as you would do for a COMT issue and would be at odds with each other.Also, have been dealing with Lyme & viruses. Does anyone have any suggestions of either someone who will work long distance with me or who is in California? Thanks, Debi
     
  6. Lynn_M

    Lynn_M Senior Member

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  7. Googsta

    Googsta Doing Well

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    Hi Rich

    I began the Simplified Protocol about 6 weeks ago, but I have only managed to take the Folinic Acid for a week & a half. I expected agitation & a worsening of symptoms, however I ended up quite suicidal. After two days of crying & feeling numb I stopped the Folinic & the next day I was fine.
    Is this a typical reaction to Methylation or is something else going on?

    I could perhaps try a lower dosage for a while, or could I take extra Methlyfolate instead & still have the same effect?

    I am doing really well otherwise, am able to walk 30 minutes most days. My psoriasis has returned shortly after starting the protocol, I am guessing that could be the immune system activating or something. It's no real bother, just looks bad.

    I would really appreciate some guidance as it is quite concerning. Thankyou for your time in helping us :)
     
  8. richvank

    richvank Senior Member

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    Hi, Alice.

    Many people have been able to restore their glutathione levels by lifting the methylation cycle block, without direct supplementation of glutathione. This treatment probably does initially lower glutathione still further, and this can make the symptoms worse at first. If this is a problem, it may be possible to support glutathione initially by adding liposomal or acetylglutathione to the protocol.

    I suggest 2 milligrams per day sublingually of hydroxoB12. Specifically, I think the Perque B12 Guard lozenge works pretty well, probably better than the liquid drops.

    I looked up the MegaFood Balance B Complex, and it actually has 400 micrograms of folate from broccoli and 125 micrograms of B12 from a yeast that is included. The broccoli-based folate may be partly folinic acid and partly methylfolate. I don't know if you would need to add more methylfolate, but perhaps so. The B12 taken orally will result in only a small amount absorbed into the blood, so more would need to be added.

    Best regards,

    Rich
     
    alice likes this.
  9. richvank

    richvank Senior Member

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    Hi, Googsta.

    It's possible that you could be one of the people whose cells are not able to use folinic acid well. Freddd has reported that he is not able to tolerate it. I would recommend that you avoid folinic acid and just use methylfolate. You can adjust the dosage to what seems to work best for you. You may need to increase it some.

    Note that folinic acid is found in some vegetables. Have you had any problems when you eat vegetables? Freddd has reported that vegetables do cause problems for him.

    Best regards,

    Rich
     
  10. alice

    alice Senior Member

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    Hi Rich
    Sorry - I as looking in the wrong column-----:oops: :redface:. I will continue with the Perque B12 SL and methylfolate in addition to the MegaFood Balance B Complex.

    I'd welcome any opinions of what the general feeling is of nutritional supplements made from fresh food, like the MegaFood brand?..
    alice
     
  11. richvank

    richvank Senior Member

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    Hi, Alice.

    The food-based ones are probably better, so long as they do contain enough of the nutrients.

    Best regards,

    Rich
     
  12. Googsta

    Googsta Doing Well

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    Hi Rich,
    thanks for your response :).
    The only vegetables containing folinic acid I am aware of are lettuce, spinach, carrots and peppers? I am fine with all of these, even in large quantities.
    The only things I am particularly sensitive to are pumpkin, sweet potato, onion, garlic & citrus though I enjoy tomatoes in moderation.

    I will try increasing the methylfolate over the next few days. Thanks again :hug:
     
  13. LisaGoddard

    LisaGoddard Senior Member

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    Hi Rich,
    I live in the UK and would like to try the methylation protocol that you suggest. Has it changed since your first
    posting on this thread of March 2011? I've found the only thing that helps so far is TMG (betaine) but I gather this is not a good thing to take.

    Is it still....1. General Vitamin Neurological Health Formula [2]:
    2. Hydroxy B12 Mega Drops [3]:
    3. MethylMate B [4]:
    4. Folinic acid [5]:
    5. Phosphatidyl Serine Complex [6]?

    Thanks for your help,
    Lisa
     
  14. Uno

    Uno Senior Member

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    This is the latest from Rich as far as I can see.....but substitute Phosphatidyl Serine for Lecethin.

    Hope this helps
    x




    SIMPLIFIED TREATMENT APPROACH
    FOR LIFTING THE METHYLATION CYCLE BLOCK
    IN CHRONIC FATIGUE SYNDROM (March 30, 2011 Revision)
    Rich Van Konynenburg. Ph.D.
    (Based on the full treatment program
    developed by Amy Yasko, Ph.D., N.D.
    which is used primarily in treating autism [1])

    SUPPLEMENTS

    1. General Vitamin Neurological Health Formula [2]: Start with one-quarter tablet and increase dosage as tolerated to 2 tablets daily
    2. Hydroxy B12 Mega Drops [3]: 2 drops under the tongue daily
    3. MethylMate B [4]: 3 drops under the tongue daily
    4. Folinic acid [5]: one-quarter capsule daily
    5. Phosphatidyl Serine Complex [6]: 1 softgel capsule daily (or lecithin, see below)

    All these supplements can be obtained from http://www.holisticheal.com.
    The fourth supplement comes in capsules that contain 800 mcg. It will be necessary to open the capsules, dump the powder onto a flat surface, and separate it into quarters using a knife to obtain the daily dose. The powder can be taken orally with water, with or without food.
    These supplements can make some patients sleepy, so in those cases they take them at bedtime. In general, they can be taken at any time of day, with or without food.
    Phosphatidyl serine can lower cortisol levels.may wish to substitute lecithin [7] (at one softgel daily) for supplement number 5 above. Lecithin is also available from http://www.holisticheal.com.
    GO SLOWLY. As the methylation cycle block is lifted, toxins are released and processed by the body, and this can lead to an exacerbation of symptoms. IF THIS HAPPENS, try smaller doses, every other day. SLOWLY Patients who already have lower than normal cortisol work up to the full dosages.
    Although this treatment approach consists only of nonprescription nutritional supplements, a few patients have reported adverse effects while on it. Therefore, it is necessary that patients be supervised by physicians while receiving this treatment.

    [1] Yasko, Amy, Autism, Pathways to Recovery, Neurological Research Institute, 2009, available from http://www.holisticheal.com or Amazon.
    [2] General Vitamin Neurological Health Formula is formulated and supplied by Holistic Health Consultants LLC.
    [3] Hydroxy B12 Mega Drops is a liquid form of hydroxocobalamin (B12), supplied by Holistic Health Consultants. 2 drops is a dosage of 2,000 mcg.
    [4] MethylMate B is a liquid form of (6s)-methyltetrahydrofolate supplied by Holistic Health Consultants, based on Extrafolate S, a trademark of Gnosis S.P.A. 3 drops is a dosage of 210 mcg.
    [5] Folinic acid is 5-formyltetrahydrofolate. one-quarter capsule is a dosage of 200 mcg.
    [5] Phosphatidyl Serine Complex is a product of Vitamin Discount Center. 1 softgel is a dosage of 500 mg.
    [7] Lecithin is a combination of phospholipids without phosphatidylserine. One softgel is a dosage of 1,200 mg.
    richvank, Mar 31, 2011
    #7
     
  15. LisaGoddard

    LisaGoddard Senior Member

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  16. richvank

    richvank Senior Member

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    Hi, Lisa.

    You might try vitaminsuk.com or mandimart.
     
  17. Lola23

    Lola23

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    Hi guys I am new to this website. I totally believe methylation is key to my healing from CFS/ fibro. Two years ago I took 800mcg folic acid and felt AMAZING for two weeks. I slept better. My back pain went away. Then all of a sudden I started to get a migraine every time I took the folic acid. Even when I halved the dose and took it a month later, I still got a migraine. Now two years later, I still can't tolerate even a quarter of a tablet of metafolin. What is going on? I also get an immediate migraine from B12...even if I nibble off the slightest bit of a tiny active B12, I get a SPLITTING headache to the point of having to lie in bed in pain for the next 24 hours.

    Does anyone know what could be going on? Or what I could do to be able to tolerate folic acid and B12? I know if I could tolerate these vitamins, I would feel much better. For some reason B6 or P5P gives me no problem at all.
     
  18. richvank

    richvank Senior Member

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    Hi, Lola.

    I don't know why folate and B12 give you bad headaches. I wonder if you might have some other deficiencies. It would be helpful if you could do some testing to find out, I think.

    Best regards,

    Rich
     
  19. Lola23

    Lola23

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    Thanks for the reply. What kind of testing should I get?
     
  20. Googsta

    Googsta Doing Well

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    Australia
    Hi Rich

    Unfortunately I am experiencing the same problems with the Methylfolate as the Folinic Acid i.e severe depression. It seemed fine at first but after one week I had the same issues. I stopped the entire protocol Thursday (Saturday here) & am still having these negative effects.

    Taking the half tablet of metafolin seemed tolerable, I was more anxious but not depressed. Would that amount be sufficient?

    Any ideas why this is happening? I wasn't depressed at all before introducing these two components. It is so frustrating!

    Thanks

    UPDATE 9th Aug: Have been feeling fine again since Sunday afternoon.
     

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