Something ive tried to talk about but which i feel isnt being discussed or understood very much at all, is a idea or theory or observation, of the effect of xmrv infection on the nervouse system, a quick story. when i was 16, 17 years old i slept with a girl who in the night i noticed her muscles ( nerves maybe ? ) were twiching quite strongly, odd i thought, but then thought nothing else about it, any way a short while later ( a week or two) i started getting quite violent muscle contractions ( would contract then release ) very strongly, i started getting this muscle or nerve moving jumping, everywhere, my arms legs face stomach, eyes chest hands even my skull. I never had this before i slept with this girl, and symptoms started very soon after, coincedence maybe. i dont think so. Of course i had the occassional eye twitch, thats normal, its nothing, but this is very very different, much more powerful and violent, with every part of my body being affected, often two parts at the same time, and it would often move around my body, and change location, with frightening speed, though sometimes a area could get stuck with the problem for days. After being tested positive for xmrv by Judy, i got to thinking about the muscle movement twitching in other ME/CFS patients, and i have found its a very common symptom So how can one catch sever and prolonged muscle twitching, that just sounds crazy, but i tell you, it only started after sleeping with that girl, never ever before, she also confirmed to me that she did this to another person she slept with the plot thickens it seems. The only way i can i see that this could actually be something that can be caught, is if a virus, or bacteria can cause these False fireings in nerves and muscles, to the degree that i have experianced for some thirty odd years. with almost every day of my life getting them in variouse parts of the body, that move around fast. So what virus could unite ME/CFS patients that also experiance this problem, one that has the long term potential for the condition never to cease even after 30 years ( im now 47) . Of course XMRV. Is there any evidence that upon infection of XMRV some patients develop this muscle twitching ? what damage or interuption could this virus be doing to our nervouse systems for such a persistent and common ( in ME possibly XMRV yet to be determined discussed ) has such damage or disruption been seen with othere retro viruses HIV, HTLV ? or could XMRV be unique in this way ? My daughter who is twelve is now starting to show the same false nerve firings in her legs, and from discussion with her it seems to me to be of the same type i experiance, I think its unlikely to be genetic, because i aquired this problem at age 17 through unprotected sex.. If this problem is indeed XMRV related ( lets not forget the high incidence of this in ME/CFS patients both xmrv and muscle twitching ) then clearly the route of transmission would appear to be saliva based, if my daughter is now infected with XMRV and this nerve damage is a early manifestation of it. i had this muscle false firings for some 15 or so years before i got ill, possibly xmrv positive and in good health all that time ? ive heard about magnesium, im more interested in the bigger picture here at present. The monkey studys, i wonder if these false nerve fireings would be missed. because i tell you, i get it bad sometimes, and a lot of people im close to do not know i have it, or have seen it, over a long period of time. I suspect its likely it would be missed in the monkey studys. Are there any references to this in the xmrv literature does anyone know ? I hope some find this interesting, and plausable, and possibly a very important piece of the puzzle, that is really being under discussed and regonized as a major symptom in xmrv positives,( I tried discussing this before, but not mutch was learned ) and by virtue ME/CFS patients the world over. if im right about this, then saying xmrv is a innocent bystander is obviously completely wrong. and there might infact be evidence of quite a profound disruption to the nervouse system or brains of infected individuals, not just immune dysfunction, how many xmrv positives have this problem i wonder ?