Taking 2x 5mg MitoQ per day has significantly decreased my fatigue levels. The effect occured within a few hours of taking my first dose. MitoQ is a form of ubiquinone specifically adapted to enter the mitochondria (with a factor 800 increase in absorption). Ubquinone is a form of CoQ10. I've previously tried large doses of CoQ10 with no effect. I have a genetic deficiency (A16V++) to produce mitochondrial SOD (Mn-SOD or SOD2), so this may be the reason why it helps me. MitoQ works as a SOD mimetic (see this paper), but on the other hand, I have tried Mn-SOD mimetics in the past, as well as Mn-SOD up-regulators, to no effect. MitoQ has also been documented to lower inflammatory cytokines (see here). MitoQ is surprisingly well-researched.