I'm curious about how many people here have had the Methylenetetrahrdrofolate Reductase DNA test? A phone consult with my enivronmental/ ME/CFS doctor resulted in a recommendation for this test. He mentioned folate and several other basic things, but it was a complex appointment and the MTHFR test barely stuck in my mind. The two other gene tests I've had for CA 125 and Cytochrome P450 were negative (the latter very much to my surprise at the time), so I wasn't expecting a positive result. However, I just received the results on Friday that I am: Positive for one copy of the C677T mutation and one copy of the A1298C mutation. There is a short description of the results on the lab sheet, but I wonder if anyone else knows a simpler breakdown. I've researched it on the net, but would like to know its implications in ME/CFS (onset? course? treatment?). I was able to get my local ARNP to order the test on the non-insurance-covered doctor's advice and she was clear that she could not interpret the results and that she was not familiar with this test. I've searched it here at PR and have found several mentions, but it would be nice to hear how many have been tested and if it's yielded any productive knowledge for anyone: thanks!