I pretty much can't tolerate any amount of methylfolate. I feel really hot, exhausted, and I can't sleep on amounts less than 250 mcg. Is this a sign that it 's working or is it a sign that I need to leave it alone? Or is it a sign that the CBS mutations need addressing? So much conflicting info out there. Here are my notable mutations MTHFR A1298C - Homozygous CBS C699T & CBS A36OA - Both Heterozygous I've been treating thyroid/adrenals/food allergies for years and I continue to get worse every year. I wonder if exploring mutations is worth the effort or should I keep searching other areas? Thanks.