Hello Friends! I have been taking antibiotics and a lot of other treatments for the last three months to treat my borreliosis and other tick-related co-infections. I stopped the antibiotics a week ago as the doctor said I needed a 3-month break for my liver and bone marrow to recover. The treatment was definitely very effective - I now rarely get headaches, I rarely have stomach aches, my OI and POTS has improved spectacularly and a host of other symptoms to long to mention has also gone away. Pretty much the only constant symptom I am left with is massive, constant, crippling exhaustion. It's not lethargy or sluggishness, it is a feeling of being totally knackered. Exercise makes it worse. Am I depressed? Would I feel better with antidepressants? In the past I have taken tricyclic antidepressants, which were horrible and made me very ill. I have also used prozac-family type antidepresants twice, for brief periods, and found them extremely helpful - but that was to deal with definite depression when my life had gone completely tits up and I was desperate. At the moment I don't feel miserable, but I do feel bored a lot (I am housebound, of course I do) and I think there is a pretty massive amount of apathy too, something that is utterly alien to my character and that I don't remember ever experiencing before. I know people with depression but not CFS say they feel tired, but is it a kind of lethargy that exercise can shake them out of, or is it persistent lack of energy and stamina? Does anyone know? One other thing, my mother has been telling me for a long time that whenever she speaks to me on the phone she thinks I am depresed. My mother has very bad CFS too, she is NOT one of those people who think CFS is depression. I am sorry this is long, but I have been agonising for quite a while over whether to try antidepresants or not. I'd really appreciate anyone's experiences, or just opinion based on what I've said. Thanks for reading.